Jasti V Ramanamma Children's Eye Care Center.
VST Center for Glaucoma Care.
J Glaucoma. 2020 Nov;29(11):1095-1100. doi: 10.1097/IJG.0000000000001628.
In this study, huge time delay was observed between first primary congenital glaucoma (PCG) symptom recognition by parents to ophthalmological diagnosis and this delay was unchanged over time. Bilateral affliction and mean presenting intraocular pressure (IOP) remained unaltered.
To compare the trends in presentation of patients with PCG over 3 different time periods at 10-year intervals (1998, 2008, and 2018) managed by a single surgeon at one of the largest tertiary eye care centers in South India.
Retrospective analysis of 313 eyes of 172 patients diagnosed to have PCG and treated at the L V Prasad Eye Institute (LVPEI) between January and December of the 3 specified years. Data collected included age at symptom recognition and at presentation, sex, affected eye, signs and symptoms, time between onset of symptoms and diagnosis (diagnostic delay), corneal clarity, and IOP.
Of the 172 patients, 48 (27.9%), 76 (44.2%), and 48 (27.9%) belonged to 1998, 2008, and 2018, respectively. Bilateral affliction (79% to 84%) was common and there was no sex predilection. The median age at recognition of first symptoms by caregivers/parents was 1 day (interquartile range, 1 to 30), and at diagnosis was 120 days (interquartile range, 30 to 378). Overall, presentation to LVPEI was delayed by >3 months in 80 (46.5%) children, and there was no statistically significant difference in the duration of delay over time (P=0.13). There was no significant difference in the mean presenting IOP over time (P>0.05).
We provide unique single center-based information of trends in the presentation of patients with PCG over 3 decades. Diagnostic delay was common, and a large number of characteristics of patients with PCG in South India have remained unchanged, particularly, age at onset and at diagnosis and laterality.
本研究中，父母首次发现原发性先天性青光眼（PCG）症状至眼科诊断之间存在巨大的时间延迟，且这种延迟随时间无变化。双眼受累和平均就诊时眼压（IOP）保持不变。
比较在印度南部一家最大的三级眼科中心，由同一位外科医生在三个不同的 10 年时间间隔（1998 年、2008 年和 2018 年）管理的 PCG 患者的就诊趋势。
对在指定年份 1 月至 12 月期间在 L V Prasad 眼研究所（LVPEI）被诊断为 PCG 并接受治疗的 172 例患者的 313 只眼进行回顾性分析。收集的数据包括症状识别和就诊时的年龄、性别、受累眼、体征和症状、症状出现至诊断的时间（诊断延迟）、角膜清晰度和 IOP。
172 例患者中，48 例（27.9%）、76 例（44.2%）和 48 例（27.9%）分别属于 1998 年、2008 年和 2018 年。双眼受累（79%至 84%）很常见，且无性别倾向。护理人员/父母首次识别症状的中位年龄为 1 天（四分位间距 1 至 30），诊断的中位年龄为 120 天（四分位间距 30 至 378）。总体而言，80 例（46.5%）患儿就诊 LVPEI 的时间延迟超过 3 个月，且随时间推移，延迟时间无统计学差异（P=0.13）。就诊时平均 IOP 随时间无显著差异（P＞0.05）。
我们提供了 30 年来单中心原发性先天性青光眼患者就诊趋势的独特信息。诊断延迟很常见，印度南部 PCG 患者的许多特征，尤其是发病和就诊年龄以及侧别，都没有改变。
