• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于多模态设备和计算机算法的体内胰腺微循环谱监测。

Multimodal Device and Computer Algorithm-Based Monitoring of Pancreatic Microcirculation Profiles In Vivo.

机构信息

From the Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College.

出版信息

Pancreas. 2020 Sep;49(8):1075-1082. doi: 10.1097/MPA.0000000000001627.

DOI:10.1097/MPA.0000000000001627
PMID:32769856
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7447165/
Abstract

OBJECTIVES

Pancreatic microcirculation has an essential role in orchestrating pancreatic homeostasis. Inherent complexity and technological limitation lead to interobserver variability and 1-sided microcirculatory data. Here, we introduce a multimodal device and computer algorithm-based platform for monitoring and visualizing integrated pancreatic microcirculation profiles.

METHODS

After anesthetizing and exposing pancreas tissue of BALB/c mice, probes of Oxygen to See, Microx TX3, and MoorVMS-LDF2 were positioned at pancreas in situ to capture the pancreatic microcirculatory oxygen (hemoglobin oxygen saturation, relative amount of hemoglobin, and partial oxygen pressure) and microhemodynamic data (microvascular blood perfusion and velocity). To assess and visualize pancreatic microcirculation profiles, raw data of pancreatic microcirculation profiles were processed and transformed using interquartile range and min-max normalization by Python and Apache ECharts.

RESULTS

The multimodal device-based platform was established and 3-dimensional microcirculatory modules were constructed. Raw data sets of pancreatic microcirculatory oxygen and microhemodynamic were collected. The outlier of data set was adjusted to the boundary value and raw data set was preprocessed. Normalized pancreatic microcirculation profiles were integrated into the 3-dimensional histogram and scatter modules, respectively. The 3-dimensional modules of pancreatic microcirculation profiles were then generated.

CONCLUSIONS

We established a multimodal device and computer algorithm-based monitoring platform for visualizing integrated pancreatic microcirculation profiles.

摘要

目的

胰腺微循环在调节胰腺稳态方面起着至关重要的作用。由于内在的复杂性和技术限制，导致了观察者间的变异性和片面的微循环数据。在这里，我们引入了一种基于多模态设备和计算机算法的平台，用于监测和可视化综合胰腺微循环谱。

方法

在麻醉并暴露 BALB/c 小鼠的胰腺组织后，将 Oxygen to See、Microx TX3 和 MoorVMS-LDF2 探头置于原位胰腺，以捕获胰腺微循环的氧（血红蛋白氧饱和度、血红蛋白相对量和部分氧分压）和微血流动力学数据（微血管血流灌注和速度）。为了评估和可视化胰腺微循环谱，使用 Python 和 Apache ECharts 对胰腺微循环谱的原始数据进行了中值范围和最小-最大值归一化处理。

结果

建立了基于多模态设备的平台，并构建了 3 维微循环模块。收集了胰腺微循环氧和微血流动力学的原始数据集。数据集的异常值被调整到边界值，原始数据集被预处理。归一化的胰腺微循环谱分别集成到 3 维直方图和散点模块中。然后生成了胰腺微循环谱的 3 维模块。

结论

我们建立了一种基于多模态设备和计算机算法的监测平台，用于可视化综合胰腺微循环谱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/0c7c20b3b840/mpa-49-1075-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/e64504645f67/mpa-49-1075-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/79d19d4e0ce3/mpa-49-1075-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/afa00f02cd0b/mpa-49-1075-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/e3c017149c84/mpa-49-1075-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/912f8d678040/mpa-49-1075-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/0c7c20b3b840/mpa-49-1075-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/e64504645f67/mpa-49-1075-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/79d19d4e0ce3/mpa-49-1075-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/afa00f02cd0b/mpa-49-1075-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/e3c017149c84/mpa-49-1075-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/912f8d678040/mpa-49-1075-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd74/7447165/0c7c20b3b840/mpa-49-1075-g006.jpg

相似文献

1
Multimodal Device and Computer Algorithm-Based Monitoring of Pancreatic Microcirculation Profiles In Vivo.基于多模态设备和计算机算法的体内胰腺微循环谱监测。
Pancreas. 2020 Sep;49(8):1075-1082. doi: 10.1097/MPA.0000000000001627.
2
Integrated pancreatic microcirculatory profiles of streptozotocin-induced and insulin-administrated type 1 diabetes mellitus.链脲佐菌素诱导及胰岛素给药的1型糖尿病的胰腺综合微循环特征
Microcirculation. 2021 Jul;28(5):e12691. doi: 10.1111/micc.12691. Epub 2021 Mar 11.
3
Pancreatic Microcirculation Profiles in the Progression of Hypertension in Spontaneously Hypertensive Rats.自发性高血压大鼠高血压进展过程中的胰腺微循环特征。
Am J Hypertens. 2021 Feb 18;34(1):100-109. doi: 10.1093/ajh/hpaa164.
4
The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis.胰腺微循环障碍对重症急性胰腺炎组织病理损伤及预后的影响
Pancreas. 2016 Feb;45(2):248-53. doi: 10.1097/MPA.0000000000000440.
5
Angiotensin-(1-7) Treatment Restores Pancreatic Microcirculation Profiles: A New Story in Acute Pancreatitis.血管紧张素-(1-7)治疗可恢复胰腺炎的胰腺微循环特征：急性胰腺炎的新故事。
Pancreas. 2020 Aug;49(7):960-966. doi: 10.1097/MPA.0000000000001609.
6
[Microcirculatory derangement and ischemia of the pancreas].[胰腺的微循环紊乱与缺血]
Nihon Geka Gakkai Zasshi. 1999 May;100(5):342-6.
7
Oxygen saturation, red blood cell tissue fraction and speed resolved perfusion - A new optical method for microcirculatory assessment.氧饱和度、红细胞组织分数和速度分辨灌注——一种用于微循环评估的新光学方法。
Microvasc Res. 2015 Nov;102:70-7. doi: 10.1016/j.mvr.2015.08.006. Epub 2015 Aug 13.
8
Uncertainty quantification of microcirculatory characteristic parameters for recognition of cardiovascular diseases.微血管特征参数的不确定性量化用于心血管疾病的识别。
Comput Methods Programs Biomed. 2023 Oct;240:107674. doi: 10.1016/j.cmpb.2023.107674. Epub 2023 Jun 9.
9
Pancreatic microcirculatory changes in experimental pancreatitis of graded severity in the rat.大鼠不同严重程度实验性胰腺炎中的胰腺微循环变化
Surgery. 1994 Nov;116(5):904-13.
10
[Microcirculatory failure of sublingual perfusion in septic-shock patients. Examination by OPS imaging and PiCCO monitoring].[脓毒性休克患者舌下灌注的微循环衰竭。通过OPS成像和PiCCO监测进行检查]
Zentralbl Chir. 2009 Jun;134(3):231-6. doi: 10.1055/s-0028-1098702. Epub 2009 Jun 17.

引用本文的文献

1
Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics.胰岛素在胰腺微循环氧分布及生物能量学中的作用。
World J Diabetes. 2022 Sep 15;13(9):765-775. doi: 10.4239/wjd.v13.i9.765.
2
Prediction of Genetic Alterations in Oncogenic Signaling Pathways in Squamous Cell Carcinoma of the Head and Neck: Radiogenomic Analysis Based on Computed Tomography Images.头颈部鳞状细胞癌中致癌信号通路遗传改变的预测：基于 CT 图像的放射基因组分析。
J Comput Assist Tomogr. 2021;45(6):932-940. doi: 10.1097/RCT.0000000000001213.
3
Integrated pancreatic microcirculatory profiles of streptozotocin-induced and insulin-administrated type 1 diabetes mellitus.

本文引用的文献

1
Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.血红蛋白携带的一氧化氮在心血管生理学中的作用：基于三气呼吸循环的新进展。
Circ Res. 2020 Jan 3;126(1):129-158. doi: 10.1161/CIRCRESAHA.119.315626. Epub 2019 Oct 8.
2
Pancreatic perfusion modulation following glucose stimulation assessed by noninvasive arterial spin labeling (ASL) MRI.通过无创动脉自旋标记（ASL）磁共振成像（MRI）评估葡萄糖刺激后胰腺灌注调节。
J Magn Reson Imaging. 2020 Mar;51(3):854-860. doi: 10.1002/jmri.26899. Epub 2019 Aug 13.
3
Weight-adapted ultra-low-dose pancreatic perfusion CT: radiation dose, image quality, and perfusion parameters.
链脲佐菌素诱导及胰岛素给药的1型糖尿病的胰腺综合微循环特征
Microcirculation. 2021 Jul;28(5):e12691. doi: 10.1111/micc.12691. Epub 2021 Mar 11.
体重调整的超低剂量胰腺灌注 CT：辐射剂量、图像质量和灌注参数。
Abdom Radiol (NY). 2019 Jun;44(6):2196-2204. doi: 10.1007/s00261-019-01938-z.
4
Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo.激光多普勒：一种用于体内测量胰岛微血管血管运动的工具。
J Vis Exp. 2018 Mar 8(133):56028. doi: 10.3791/56028.
5
Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat.自发性高血压大鼠的微血管血管舒缩功能受损。
Sci Rep. 2017 Dec 6;7(1):17080. doi: 10.1038/s41598-017-17013-w.
6
Insulin treatment restores islet microvascular vasomotion function in diabetic mice.胰岛素治疗可恢复糖尿病小鼠胰岛微血管舒缩运动功能。
J Diabetes. 2017 Oct;9(10):958-971. doi: 10.1111/1753-0407.12516. Epub 2017 Feb 21.
7
The Vascular Microarchitecture of the Human Fetal Pancreas: A Corrosion Casting and Scanning Electron Microscopy Study.人类胎儿胰腺的血管微观结构：一项铸型腐蚀和扫描电子显微镜研究
Pancreas. 2017 Jan;46(1):124-130. doi: 10.1097/MPA.0000000000000719.
8
Near infrared spectroscopy (NIRS) derived tissue oxygenation in critical illness.近红外光谱技术（NIRS）在危重症中用于测定组织氧合情况。
Clin Invest Med. 2015 Oct 7;38(5):E285-95. doi: 10.25011/cim.v38i5.25685.
9
Assessment of pancreatic adenocarcinoma: Use of low-dose whole pancreatic CT perfusion and individualized dual-energy CT scanning.胰腺腺癌的评估：低剂量全胰腺CT灌注及个体化双能量CT扫描的应用
J Med Imaging Radiat Oncol. 2015 Oct;59(5):590-8. doi: 10.1111/1754-9485.12342. Epub 2015 Jul 29.
10
Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis.血管舒缓激肽对重症急性胰腺炎大鼠胰腺微循环及血液流变学的影响。
Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50.