Sandermann H
Gesellschaft für Strahlen- und Umweltforschung mbH München, Institut für Biochemische Pflanzenpathologie, Neuherberg, F.R.G.
Mutat Res. 1988 Feb;197(2):183-94. doi: 10.1016/0027-5107(88)90092-9.
Genetic evidence has indicated that plants can activate certain xenobiotics to mutagens, but biochemical evidence is as yet scarce. Nevertheless, plant microsomal enzymes and peroxidases have been shown to form reactive intermediates, the best studied examples being 2-aminofluorene, benzo[a]pyrene and pentachlorophenol. The latter two xenobiotics are converted to quinoid derivatives which are, in principle, able to redox cycle and generate active oxygen species. In analogy to results obtained in mammalian systems, covalent binding of reactive intermediates to DNA as well as fragmentation of DNA, are proposed as major mechanisms of action of mutagenic plant metabolites.
遗传证据表明，植物可将某些外源性物质激活为诱变剂，但生化证据目前还很缺乏。尽管如此，植物微粒体酶和过氧化物酶已被证明能形成反应性中间体，研究得最充分的例子是2-氨基芴、苯并[a]芘和五氯苯酚。后两种外源性物质会转化为醌类衍生物，原则上，这些衍生物能够进行氧化还原循环并产生活性氧。与在哺乳动物系统中获得的结果类似，反应性中间体与DNA的共价结合以及DNA的断裂，被认为是植物诱变代谢产物的主要作用机制。
