Velemínský J, Gichner T
Institute of Experimental Botany, Czechoslovak Academy of Sciences, Prague.
Mutat Res. 1988 Feb;197(2):221-42. doi: 10.1016/0027-5107(88)90095-4.
This review summarizes data concerning mutagenic activity of promutagens in various plant in vivo assays. These data are compared with the present knowledge about the metabolism of xenobiotics and activation of promutagens in plants obtained by biochemical studies and by the separation of the activation process from the genetic endpoints assayed for the mutagenicity. The article documents a differential response of plant species in the endogenous transforming of various classes of promutagens into mutagens. Attention is devoted to the following types of promutagens: nitrosamines, polycyclic aromatic hydrocarbons and aromatic amines, aflatoxins, pyrrolizidine alkaloids, diallate, styrene, vinylchloride, ethanol, cycasin, nitrofurans, sodium azide, s-triazine herbicides, 1,2-dibromoethane and maleic hydrazide.
本综述总结了关于前诱变剂在各种植物体内试验中的诱变活性的数据。这些数据与目前通过生化研究以及将激活过程与用于检测诱变性的遗传终点分离而获得的关于植物中外源生物代谢和前诱变剂激活的知识进行了比较。本文记录了植物物种在将各类前诱变剂内源性转化为诱变剂方面的差异反应。重点关注以下几种前诱变剂：亚硝胺、多环芳烃和芳香胺、黄曲霉毒素、吡咯里西啶生物碱、燕麦敌、苯乙烯、氯乙烯、乙醇、苏铁素、硝基呋喃、叠氮化钠、三嗪类除草剂、1,2 - 二溴乙烷和顺丁烯二酸酰肼。
