Hospital Infantil João Paulo II - FHEMIG, Brazil.
Program in Rehabilitation Sciences, Universidade Federal de Minas Gerais, Brazil.
Exp Physiol. 2020 Sep;105(9):1571-1578. doi: 10.1113/EP088764. Epub 2020 Aug 14.
What is the central question of this study? How do peripheral muscle tissue oxygenation and physical conditioning levels of children and adolescents with cystic fibrosis compare to demographically matched controls? What is the main finding and its importance? Children and adolescents with cystic fibrosis consumed more oxygen, more quickly and exhibited slower recovery, demonstrating that there may have been deficiencies in oxygen supply related to both oxygen uptake and oxygen transport.
Cystic fibrosis affects skeletal muscle performance and functional capacity. However, it is currently unclear how peripheral muscle behaviour is affected, especially in children and adolescents. To examine this, we compared tissue oxygenation of children and adolescents with cystic fibrosis against healthy volunteers. We also evaluated the functional capacity of participants via the modified shuttle test (MST) and assessed for associations between performance and near-infrared spectroscopy. A total of 124 participants enrolled. Participants were divided into either the cystic fibrosis group (CFG) or the healthy group (HG). Statistical comparisons between groups were evaluated with the Mann-Whitney U test and associations with functional capacity were evaluated using Spearman's correlation coefficient. CFG volunteers scored lower on the MST compared to the HG. They walked shorter distances (P = 0.001) with less efficiency because they performed the tests with a less efficient walking economy (P = 0.001) and a greater deoxyhaemoglobin concentration (P = 0.001). Further, they experienced reduced tissue oxygen saturation (P = 0.037) faster than the HG. As a result, they presented lower respiratory (P = 0.001) and lower heart (P = 0.001) rate values at the end of the MST, with a longer post-test heart rate recovery time (P = 0.005). There was a significant association between deoxygenation time and functional capacity. The CFG consumed more oxygen, more quickly, with a slower recovery, reflecting impairments in the dynamics of muscle oxygen extraction. The results suggest differences in functional capacity and haemodynamic recovery in children and adolescents with cystic fibrosis.
本研究的核心问题是什么？囊性纤维化患儿和青少年的外周肌肉组织氧合和身体适应水平与人口统计学匹配的对照组相比如何？主要发现及其重要性是什么？囊性纤维化患儿和青少年消耗更多氧气，速度更快，恢复更慢，这表明氧气摄取和氧气输送相关的氧气供应可能存在不足。
囊性纤维化会影响骨骼肌的表现和功能能力。然而，目前尚不清楚外周肌肉的行为如何受到影响，尤其是在儿童和青少年中。为了研究这一点，我们比较了囊性纤维化患儿和青少年的组织氧合与健康志愿者。我们还通过改良 shuttle 测试 (MST) 评估了参与者的功能能力，并评估了性能与近红外光谱之间的相关性。共有 124 名参与者入组。参与者被分为囊性纤维化组 (CFG) 或健康组 (HG)。使用 Mann-Whitney U 检验评估组间的统计学差异，使用 Spearman 相关系数评估与功能能力的相关性。CFG 志愿者在 MST 中的得分低于 HG。他们走的距离更短 (P = 0.001)，效率更低，因为他们以效率更低的步行经济性进行测试 (P = 0.001) 和更高的脱氧血红蛋白浓度 (P = 0.001)。此外，他们的组织氧饱和度下降更快 (P = 0.037)。结果，他们在 MST 结束时表现出更低的呼吸率 (P = 0.001) 和更低的心率 (P = 0.001)，并且在测试后心率恢复时间更长 (P = 0.005)。脱氧时间与功能能力之间存在显著相关性。CFG 消耗更多氧气，速度更快，恢复更慢，这反映了肌肉氧摄取动力学的损伤。结果表明囊性纤维化患儿和青少年的功能能力和血液动力学恢复存在差异。
