Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Akdeniz University, 07070, Antalya, Turkey.
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
Eur J Pediatr. 2022 Aug;181(8):2891-2900. doi: 10.1007/s00431-022-04490-z. Epub 2022 May 10.
Primary ciliary dyskinesia (PCD) impairs pulmonary function, respiratory and peripheral muscle strength, and exercise capacity. We aimed to investigate the effects of active video games (AVGs) on pulmonary function, respiratory and peripheral muscle strength, exercise capacity, muscle oxygenation (SMO), physical activity, activities of daily living (ADL), and quality of life (QOL) in PCD. Thirty-two PCD patients were randomly assigned to AVG group (n = 16) and the control group (n = 16). AVG group underwent AVGs using Xbox-Kinect-360 device for 40 min/day, 3 days/week for 8 weeks plus airway clearance techniques (ACT), and the control group was applied ACT only. Pulmonary function, respiratory and quadriceps muscle strength, exercise capacity (6-min walk test [6MWT], incremental shuttle walk test [ISWT]), and ADL (Glittre ADL test) were assessed. SMO during ISWT and ADL test was also recorded. Physical activity and QOL (PCD-QOL) were evaluated. Pulmonary function; respiratory and quadriceps muscle strength; 6MWT and ISWT distance; physical activity; ADL performance; SMO; physical, emotional, and social functioning; treatment burden; and upper and lower symptom parameters of PCD-QOL significantly improved after 8 weeks in the AVG group (p < 0.05). There were no significant differences in measured parameters except emotional function and upper respiratory symptom scores of PCD-QOL in the control group (p > 0.05). Conclusion: The AVGs positively affect pulmonary (pulmonary function, respiratory muscle strength) and extrapulmonary (peripheral muscle strength, exercise capacity, SMO, physical activity, ADL, and QOL) characteristics in children with PCD. The AVGs may be added to the pulmonary rehabilitation program as an exercise training modality in patients with PCD. Trial registration: This study registered at ClinicalTrials.gov with NCT03832491 on February 6, 2019. What is Known: • It is indicated that exercise capacity is increased with traditional exercise-training in a case report of Kartagener Syndrome. What is New: • No randomized controlled study investigated the effects of exercise-training in PCD. • 8-week moderate-intensity active video gaming (AVGs) improves pulmonary and extrapulmonary features in children with PCD. AVGs may be preferable due to being enjoyable, providing visual and audial feedback in the pulmonary rehabilitation programs of PCD.
原发性纤毛运动障碍 (PCD) 会损害肺功能、呼吸和外周肌肉力量以及运动能力。我们旨在研究主动视频游戏 (AVG) 对 PCD 患者肺功能、呼吸和外周肌肉力量、运动能力、肌肉氧合 (SMO)、身体活动、日常生活活动 (ADL) 和生活质量 (QOL) 的影响。32 名 PCD 患者被随机分配到 AVG 组 (n=16) 和对照组 (n=16)。AVG 组使用 Xbox-Kinect-360 设备进行 40 分钟/天、3 天/周、8 周的 AVG 治疗，外加气道清除技术 (ACT)，对照组仅接受 ACT。评估了肺功能、呼吸和股四头肌力量、运动能力 (6 分钟步行测试 [6MWT]、递增穿梭步行测试 [ISWT]) 和 ADL (Glittre ADL 测试)。还记录了 ISWT 和 ADL 测试期间的 SMO。评估了身体活动和 QOL (PCD-QOL)。8 周后，AVG 组的肺功能；呼吸和股四头肌力量；6MWT 和 ISWT 距离；身体活动；ADL 表现；SMO；身体、情绪和社会功能；治疗负担；以及 PCD-QOL 的上呼吸道和下呼吸道症状参数均显著改善 (p<0.05)。对照组除情绪功能和 PCD-QOL 的上呼吸道症状评分外，其他测量参数均无显著差异 (p>0.05)。结论：AVG 对 PCD 儿童的肺部 (肺功能、呼吸肌力量) 和肺外 (外周肌肉力量、运动能力、SMO、身体活动、ADL 和 QOL) 特征有积极影响。AVG 可作为 PCD 患者肺康复计划中的一种运动训练方式。试验注册：本研究于 2019 年 2 月 6 日在 ClinicalTrials.gov 注册，注册号为 NCT03832491。已知：•有病例报告表明，在 Kartagener 综合征中，传统运动训练可增加运动能力。新发现：•尚无随机对照研究调查 PCD 患者运动训练的效果。•8 周中等强度的主动视频游戏 (AVG) 可改善 PCD 儿童的肺部和肺外特征。由于 AVG 具有趣味性，可提供视觉和听觉反馈，因此在 PCD 的肺康复计划中可能更受欢迎。
