Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.
Laryngoscope. 2021 Apr;131(4):E1125-E1129. doi: 10.1002/lary.28966. Epub 2020 Aug 8.
To evaluate the rate of lymph node metastasis in parotid gland acinar cell carcinoma, to identified factors associated with increased risk of metastasis, and to evaluate the effect of nodal metastasis on survival.
This is a retrospective cohort study utilizing data from a large population-based cancer database. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 database. The study cohort included patients with parotid gland acinar cell carcinoma diagnosed between 2000 and 2015.
The overall rate of lymph node metastasis was 6.8%. T3/T4 (OR 6.17, 95% CI, 3.03 to 13.16) disease along with High Grade (OR 15.95) disease were associated with increased risk of nodal metastasis. Non-white, non-Black race was associated with decreased risk. Age and sex were not associated with nodal metastasis. Nodal metastasis was associated with worse OS (HR 6.27, 95% CI, 3.85 to 10.20) and DSS (HR 6.96, 95% CI, 3.81 to 12.73) after adjusting for covariates.
Parotid gland acinar cell carcinoma carries a low risk of nodal metastasis. Both advanced T stage and high grade are associated with increased risk of nodal metastasis. Nodal metastasis is associated with decreased overall survival.
3 Laryngoscope, 131:E1125-E1129, 2021.
评估腮腺腺泡细胞癌的淋巴结转移率，确定与转移风险增加相关的因素，并评估淋巴结转移对生存的影响。
这是一项利用大型基于人群的癌症数据库数据进行的回顾性队列研究。数据从监测、流行病学和最终结果（SEER）18 数据库中提取。研究队列包括 2000 年至 2015 年间诊断为腮腺腺泡细胞癌的患者。
淋巴结转移的总发生率为 6.8%。T3/T4 期（OR6.17，95%CI3.03 至 13.16）疾病和高级别（OR15.95）疾病与淋巴结转移风险增加相关。非白种人、非黑种人种族与较低的风险相关。年龄和性别与淋巴结转移无关。在调整了协变量后，淋巴结转移与较差的总生存（HR6.27，95%CI3.85 至 10.20）和疾病特异性生存（HR6.96，95%CI3.81 至 12.73）相关。
腮腺腺泡细胞癌淋巴结转移风险低。晚期 T 分期和高级别均与淋巴结转移风险增加相关。淋巴结转移与总生存率降低相关。
3 级 Laryngoscope，131：E1125-E1129，2021 年。
