Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
Department Otolaryngology Head and Neck Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
Eur Arch Otorhinolaryngol. 2022 Dec;279(12):5821-5829. doi: 10.1007/s00405-022-07481-w. Epub 2022 Jun 9.
To analyze the demographic data, surgical and adjuvant treatment data and the survival outcomes in adult patients affected by acinic cell carcinoma of the parotid gland (AciCC).
A retrospective multicenter analysis of patients treated for AciCC of the parotid gland from 2000 to 2021 was performed. Exclusion criteria were pediatric (0-18 years) patients, the absence of follow-up and patients with secondary metastatic disease to the parotid gland. Multivariable logistic regression was used to determine factors associated with survival.
The study included 81 adult patients with AciCC of the parotid gland. The median age was 46.3 years (SD 15.81, range 19-84 years), with a gender female prevalence (F = 48, M = 33). The mean follow-up was 77.7 months (min 4-max 361, SD 72.46). The 5 years overall survival (OS) was 97.5%. The 5 years disease-free survival (DFS) was 60%. No statistical differences have been found in prognosis for age (< 65 or ≥ 65 years), sex, surgery type (superficial vs profound parotid surgery), radicality (R0 vs R1 + Rclose), neck dissection, early pathologic T and N stages and adjuvant therapy (p > 0.05).
This study did not find prognostic factor for poorest outcome. In contrast with the existing literature, our results showed how also high-grade tumours cannot be considered predictive of recurrence or aggressive behaviour.
分析成人腮腺腺样囊性癌（AciCC）患者的人口统计学数据、手术和辅助治疗数据以及生存结果。
对 2000 年至 2021 年期间接受腮腺 AciCC 治疗的患者进行回顾性多中心分析。排除标准为儿科（0-18 岁）患者、缺乏随访和腮腺继发性转移性疾病患者。多变量逻辑回归用于确定与生存相关的因素。
本研究纳入了 81 例腮腺 AciCC 成年患者。中位年龄为 46.3 岁（标准差 15.81，范围 19-84 岁），女性患病率较高（F=48，M=33）。平均随访时间为 77.7 个月（最短 4 个月，最长 361 个月，标准差 72.46）。5 年总生存率（OS）为 97.5%。5 年无病生存率（DFS）为 60%。年龄（<65 岁或≥65 岁）、性别、手术类型（腮腺浅叶或深叶切除术）、根治性（R0 或 R1+Rclose）、颈清扫术、早期病理 T 和 N 分期以及辅助治疗对预后无统计学差异（p>0.05）。
本研究未发现预后最差的预测因素。与现有文献相比，我们的结果表明，高级别肿瘤也不能被认为是复发或侵袭性行为的预测因素。
