Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
Am J Reprod Immunol. 2020 Dec;84(6):e13318. doi: 10.1111/aji.13318. Epub 2020 Aug 28.
Varicocele may lead to testicular dysfunction and male infertility. Varicocelectomy can improve both semen quality and post-operative spontaneous pregnancy. However, different patients benefit distinctly from the surgery. Therefore, the study aims at examining the possible factors of spontaneous pregnancy after laparoscopic varicocelectomy in infertile men.
Clinical data of 196 infertile men who underwent laparoscopic varicocelectomy at our institute were collected from December 2013 to February 2019. Follow-up data were available for 148 patients. All the patients were treated with laparoscopic varicocelectomy performed by experienced urological doctors. Possible pre-operative factors of spontaneous pregnancy after laparoscopic varicocelectomy were retrospectively analyzed.
After a mean follow-up of 29.1 ± 12.6 months (range 12-74 months), 74 (50%) of couples achieved spontaneous pregnancy. Univariate analysis revealed that short infertility duration, secondary infertility, and high sperm progressive motility were significant predictors of spontaneous pregnancy after laparoscopic varicocelectomy. Multivariate analysis revealed that short infertility duration (≤2 years) and high sperm progressive motility (>30%) were independent predictors.
Both infertility duration and pre-operative sperm progressive motility could serve as independent factors of spontaneous pregnancy after laparoscopic varicocelectomy.
精索静脉曲张可能导致睾丸功能障碍和男性不育。精索静脉结扎术可以改善精液质量和术后自然妊娠。然而，不同的患者从手术中获益明显不同。因此，本研究旨在探讨精索静脉结扎术后不孕男性自然妊娠的可能因素。
收集 2013 年 12 月至 2019 年 2 月我院 196 例接受腹腔镜精索静脉结扎术的不孕男性的临床资料，随访资料 148 例。所有患者均由经验丰富的泌尿外科医生行腹腔镜精索静脉结扎术治疗。回顾性分析腹腔镜精索静脉结扎术后自然妊娠的可能术前因素。
平均随访 29.1±12.6 个月（范围 12-74 个月）后，74 对夫妇（50%）自然妊娠。单因素分析显示，不孕时间短、继发不孕、精子前向运动能力高是腹腔镜精索静脉结扎术后自然妊娠的显著预测因素。多因素分析显示，不孕时间短（≤2 年）和精子前向运动能力高（>30%）是独立的预测因素。
不孕时间和术前精子前向运动能力均可作为腹腔镜精索静脉结扎术后自然妊娠的独立因素。
