Department of Oral and Maxillofacial Surgery, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Department of Dermatology and Venereology, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Haidari 124 62, Athens, Greece.
Arch Dermatol Res. 2021 Jul;313(5):373-380. doi: 10.1007/s00403-020-02113-x. Epub 2020 Aug 8.
Cytokines involved in inflammatory and immune response have been associated with risk for development of basal cell carcinoma (BCC). In this study, three functional DNA polymorphisms affecting gene expression were investigated in 54 BCC patients and 111 healthy controls: interleukin-1b (IL-1b) +3953C/T, interleukin-10 (IL-10) - 1082G/A and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms. Significant increase of the variant alleles was observed in IL-10 - 1082G (P = 0.019) and in ACE D (P = 0.003) in BCC patients in comparison to controls. Multivariate logistic regression models evaluated the contribution of homozygous and heterozygous variant polymorphisms to the risk for BCC development. The studied polymorphisms influencing the expression of IL-10 and ACE genes were recognized as potential predictive factors for BCC. These findings suggest a possible molecular mechanism leading to BCC development that is likely to involve the activation of angiotensin receptors in combination with increased plasma levels of IL-10 in patients.
参与炎症和免疫反应的细胞因子与基底细胞癌 (BCC) 发展的风险有关。在这项研究中，研究了影响基因表达的三个功能性 DNA 多态性，涉及 54 名 BCC 患者和 111 名健康对照者：白细胞介素-1b (IL-1b) +3953C/T、白细胞介素-10 (IL-10) -1082G/A 和血管紧张素转换酶 (ACE) 插入/缺失 (I/D) 多态性。与对照组相比，BCC 患者中 IL-10-1082G (P=0.019) 和 ACE D (P=0.003) 的变异等位基因显著增加。多变量逻辑回归模型评估了纯合子和杂合子变异多态性对 BCC 发展风险的贡献。研究表明，影响 IL-10 和 ACE 基因表达的多态性是 BCC 的潜在预测因子。这些发现表明，一种可能的分子机制可能导致 BCC 的发展，这可能涉及到血管紧张素受体的激活，以及患者血浆中 IL-10 水平的升高。
