Zambrano-Román Marianela, Padilla-Gutiérrez Jorge R, Valle Yeminia, Muñoz-Valle José F, Valdés-Alvarado Emmanuel
Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Ciencias Biomédicas (IICB), Universidad de Guadalajara, Guadalajara 44340, Mexico.
Doctorado en Genética Humana, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Cancers (Basel). 2022 May 11;14(10):2371. doi: 10.3390/cancers14102371.
Skin cancer is one of the main types of cancer worldwide, and non-melanoma skin cancer (NMSC) is the most frequent within this group. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common types. Multifactorial features are well-known for cancer development, and new hallmarks are gaining relevance. Genetics and epigenetic regulation play an essential role in cancer susceptibility and progression, as well as the variety of cells and molecules that interact in the tumor microenvironment. In this review, we provide an update on the genetic features of NMSC, candidate genes, and new therapies, considering diverse perspectives of skin carcinogenesis. The global health situation and the pandemic have been challenging for health care systems, especially in the diagnosis and treatment of patients with cancer. We provide innovative approaches to overcome the difficulties in the current clinical dynamics.
皮肤癌是全球主要的癌症类型之一，非黑色素瘤皮肤癌（NMSC）是该组中最常见的。基底细胞癌（BCC）和鳞状细胞癌（SCC）是最常见的类型。癌症发展的多因素特征是众所周知的，新的特征也越来越重要。遗传学和表观遗传调控在癌症易感性和进展中起着至关重要的作用，以及在肿瘤微环境中相互作用的各种细胞和分子。在这篇综述中，我们从皮肤致癌作用的不同角度，提供了关于NMSC的遗传特征、候选基因和新疗法的最新信息。全球健康状况和大流行对医疗保健系统构成了挑战，尤其是在癌症患者的诊断和治疗方面。我们提供创新方法以克服当前临床动态中的困难。
