抗胸腺细胞球蛋白诱导长期存活的大鼠心脏同种异体移植物的形态学

Morphology of rat cardiac allografts with permanent survival induced by antithymocyte globulin.

作者信息

Claesson K, Mjörnstedt L, Klareskog L, Larsson E, Olausson M, Söderström T

机构信息

Department of Urology, University of Uppsala, Sweden.

出版信息

Scand J Immunol. 1988 Feb;27(2):171-9. doi: 10.1111/j.1365-3083.1988.tb02336.x.

DOI:10.1111/j.1365-3083.1988.tb02336.x

PMID:3277262

Abstract

In a rat heart transplantation model, permanent graft survival was achieved by anti-thymocyte globulin (ATG) treatment of Wistar Kyoto (WKy) recipients before grafting with PVG/c hearts. Nine hearts with palpable and electrocardiographic (ECG) function 8-20 months after transplantation were studied with histological and immunohistochemical methods. The dominating findings were fibrosis, intimal thickening, thrombosis of vessels, cellular infiltrates, and a high number of cells expressing class II antigens. These findings suggest that reactions compatible with a chronic rejection can be found in long-term surviving rat heart allografts. This rat model may thus be used in further studies of a chronic rejection process.

摘要

在大鼠心脏移植模型中，通过在将PVG/c心脏移植给Wistar Kyoto（WKy）受体之前用抗胸腺细胞球蛋白（ATG）对受体进行治疗，实现了移植物的长期存活。对移植后8至20个月具有可触及搏动和心电图（ECG）功能的9颗心脏进行了组织学和免疫组织化学研究。主要发现包括纤维化、内膜增厚、血管血栓形成、细胞浸润以及大量表达II类抗原的细胞。这些发现表明，在长期存活的大鼠心脏同种异体移植物中可发现与慢性排斥反应相符的反应。因此，该大鼠模型可用于慢性排斥反应过程的进一步研究。