抗胸腺细胞球蛋白诱导成年大鼠移植耐受中的抑制细胞

Suppressor cells in antithymocyte globulin-induced transplantation tolerance in the adult rat.

作者信息

Olausson M, Mjörnstedt L, Lindholm L, Brynger H

出版信息

Int Arch Allergy Appl Immunol. 1984;75(2):184-7. doi: 10.1159/000233611.

Abstract

A rat heart allograft model, for induction of transplantation tolerance by a single dose of antithymocyte globulin, was studied. Experiments were made to transfer the tolerance to syngeneic recipients, either by spleen cells or sera obtained from tolerant rats. Different doses of tolerant spleen cells caused long-term surviving (LTS) allografts when transferred to sublethally irradiated recipients. Spleen cell transfer to untreated recipients resulted in prolonged allograft survival but no LTS grafts. The results indicate the presence of a cell-mediated suppressor mechanism in the tolerant animals.

摘要

研究了一种大鼠心脏同种异体移植模型，该模型通过单剂量抗胸腺细胞球蛋白诱导移植耐受。进行了实验，将耐受性大鼠的脾细胞或血清转移至同基因受体以传递耐受性。不同剂量的耐受性脾细胞转移至亚致死剂量照射的受体时，可导致同种异体移植长期存活（LTS）。将脾细胞转移至未处理的受体可导致同种异体移植存活时间延长，但无LTS移植。结果表明，在耐受性动物中存在细胞介导的抑制机制。