Senior Resident, Department of Medicine, Dayanand Medical College, Ludhiana, India.
Professor, Department of Medicine, Maharishi Markandeshwar Institute of Medical Sciences & Research, Mullana, Ambala, India.
Trop Doct. 2021 Apr;51(2):181-184. doi: 10.1177/0049475520945058. Epub 2020 Aug 9.
Apart from its association with metabolic syndrome and diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) has been thought to be linked with other endocrine and metabolic disorders. Recent data suggest that hypothyroidism may be a significant risk factor for development and progression of NAFLD. The present study was conducted to evaluate the presence of NAFLD in patients with hypothyroidism presenting to a rural tertiary care centre in north India. The diagnosis of NAFLD was made on the basis of radiological findings and derangement of liver enzymes. Our findings showed that ultrasonographic evidence of fatty liver as well as increase in the serum transaminase level above normal range were significantly higher in hypothyroidism patients as compared with controls. On multivariate regression analysis of the patients' data, the presence of hypothyroidism was independently associated with risk of NAFLD. We therefore conclude that hypothyroidism is a significant independent risk factor.
除了与代谢综合征和糖尿病有关外，非酒精性脂肪肝（NAFLD）也被认为与其他内分泌和代谢紊乱有关。最近的数据表明，甲状腺功能减退症可能是 NAFLD 发生和进展的一个重要危险因素。本研究旨在评估在印度北部农村三级医疗中心就诊的甲状腺功能减退症患者中是否存在 NAFLD。NAFLD 的诊断基于影像学发现和肝脏酶的紊乱。我们的研究结果表明，与对照组相比，甲状腺功能减退症患者的超声检查有脂肪肝的证据，以及血清转氨酶水平升高超过正常范围，这两种情况的发生率明显更高。对患者数据的多变量回归分析表明，甲状腺功能减退症的存在与 NAFLD 的风险独立相关。因此，我们得出结论，甲状腺功能减退症是一个重要的独立危险因素。
