Elhence Anshuman, Bansal Bhavik, Gupta Hardik, Anand Abhinav, Singh Thakur P, Goel Amit
All India Institute of Medical Sciences, New Delhi, India.
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
J Clin Exp Hepatol. 2022 May-Jun;12(3):818-829. doi: 10.1016/j.jceh.2021.11.010. Epub 2021 Nov 25.
Non-alcoholic fatty liver disease (NAFLD) contributes to a large proportion of liver disease burden in the world. Several groups have studied the prevalence of NAFLD in the Indian population.
A systematic review of the published literature and meta-analysis was carried out to estimate the prevalence of NAFLD in the Indian population.
English language literature published until April 2021 was searched from electronic databases. Original data published in any form which had reported NAFLD prevalence in the Indian population were included. The subgroup analysis of prevalence was done based on the age (adults or children) and risk category, i.e., average-risk group (community population, participants of control arm, unselected participants, hypothyroidic individuals, athletes, aviation crew, and army personnel) and high-risk group (obesity or overweight, diabetes mellitus, coronary artery disease, etc.). The prevalence estimates were pooled using the random-effects model. Heterogeneity was assessed with I.
Sixty-two datasets (children 8 and adults 54) from 50 studies were included. The pooled prevalence of NAFLD was estimated from 2903 children and 23,581 adult participants. Among adults, the estimated pooled prevalence was 38.6% (95% CI 32-45.5). The NAFLD prevalence in average-risk and high-risk subgroups was estimated to be 28.1% (95% CI 20.8-36) and 52.8% (95% CI 46.5-59.1), respectively. The estimated NAFLD prevalence was higher in hospital-based data (40.8% [95% CI 32.6-49.3%]) than community-based data (28.2% [95% CI 16.9-41%]). Among children, the estimated pooled prevalence was 35.4% (95% CI 18.2-54.7). The prevalence among non-obese and obese children was 12.4 (95% CI 4.4-23.5) and 63.4 (95% CI 59.4-67.3), respectively.
Available data suggest that approximately one in three adults or children have NAFLD in India.
非酒精性脂肪性肝病（NAFLD）在全球肝病负担中占很大比例。多个研究团队对印度人群中NAFLD的患病率进行了研究。
对已发表的文献进行系统综述和荟萃分析，以估计印度人群中NAFLD的患病率。
从电子数据库中检索截至2021年4月发表的英文文献。纳入以任何形式发表的、报告了印度人群中NAFLD患病率的原始数据。根据年龄（成人或儿童）和风险类别进行患病率亚组分析，即平均风险组（社区人群、对照组参与者、未选择的参与者、甲状腺功能减退者、运动员、航空机组人员和军队人员）和高风险组（肥胖或超重、糖尿病、冠状动脉疾病等）。使用随机效应模型汇总患病率估计值。用I²评估异质性。
纳入了来自50项研究的62个数据集（儿童8个，成人54个）。NAFLD的汇总患病率是根据2903名儿童和23581名成人参与者估计得出的。在成人中，估计的汇总患病率为38.6%（95%置信区间32 - 45.5）。平均风险亚组和高风险亚组中NAFLD的患病率估计分别为28.1%（95%置信区间20.8 - 36）和52.8%（95%置信区间46.5 - 59.1）。基于医院的数据中估计的NAFLD患病率（40.8% [95%置信区间32.6 - 49.3%]）高于基于社区的数据（28.2% [95%置信区间16.9 - 41%]）。在儿童中，估计的汇总患病率为35.4%（95%置信区间18.2 - 54.7）。非肥胖儿童和肥胖儿童中的患病率分别为12.4（95%置信区间4.4 - 23.5）和63.4（95%置信区间59.4 - 67.3）。
现有数据表明，在印度，约三分之一的成人或儿童患有NAFLD。
