甲状腺功能减退与非酒精性脂肪性肝病之间关联的证据：一项更新的系统评价。
Evidence on the link between hypothyroidism and non-alcoholic fatty liver disease: an updated systematic review.
作者信息
Pourseyedi Nazanin, Arefhosseini Sara, Tutunchi Helda, Ebrahimi-Mameghani Mehrangiz
机构信息
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
BMC Endocr Disord. 2025 Jul 1;25(1):154. doi: 10.1186/s12902-025-01977-2.
BACKGROUND
Numerous studies have investigated the relationship between hypothyroidism and non-alcoholic fatty liver disease (NAFLD), while the underlying mechanisms are not well understood. This systematic review evaluated the mentioned relationship among non-diabetic adults.
METHODS
This systematic review was written in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar until January 2024. After a critical analysis, 29 observational studies were included in the present systematic review.
RESULTS
The available observational evidence suggests a potential association between hypothyroidism and NAFLD. Regarding this complex relationship, patients with hypothyroidism may be more likely to develop NAFLD compared to those with normal thyroid function. Several factors are involved in the development of hypothyroidism-induced NAFLD.
CONCLUSIONS
Thyroid hormones regulate energy and metabolism, suggesting their relevance in NAFLD. Increased awareness and optimized strategies are needed for mutual screening and managing thyroid disease and NAFLD coexistence.
背景
众多研究已对甲状腺功能减退症与非酒精性脂肪性肝病（NAFLD）之间的关系进行了调查，但其潜在机制尚未完全明确。本系统评价评估了非糖尿病成年人中上述关系。
方法
本系统评价按照系统评价和Meta分析的首选报告项目（PRISMA）指南撰写。使用PubMed、Scopus、科学网和谷歌学术进行全面的文献检索，直至2024年1月。经过严格分析，本系统评价纳入了29项观察性研究。
结果
现有观察性证据表明甲状腺功能减退症与NAFLD之间可能存在关联。关于这种复杂关系，与甲状腺功能正常者相比，甲状腺功能减退症患者更易发生NAFLD。甲状腺功能减退症所致NAFLD的发生涉及多个因素。
结论
甲状腺激素调节能量和代谢，提示其与NAFLD相关。对于甲状腺疾病和NAFLD共存的相互筛查和管理，需要提高认识并优化策略。
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