Spillert C R, Curtis G T, Lazaro E J
Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103.
South Med J. 1988 Feb;81(2):164-6. doi: 10.1097/00007611-198802000-00005.
Monocyte dysfunction has been reported in patients with cancer. The generation of a procoagulant tissue factor is a marker of the monocyte's activation. Since the only blood cell capable of generating tissue factor is the monocyte, the incubation of citrated blood with either saline (control) or endotoxin (monocyte activator) followed by determination of the recalcification time should yield a measure of monocyte activation. The recalcification times of the saline-incubated samples were similar for healthy women and those with cystic hyperplasia, but were significantly shortened in patients with breast cancer. The recalcification times of the endotoxin-activated samples were significantly shorter in patients with breast cancer than in those with cystic hyperplasia, which in turn was significantly shorter than in healthy women.
癌症患者中已报道存在单核细胞功能障碍。促凝血组织因子的产生是单核细胞激活的一个标志物。由于唯一能够产生组织因子的血细胞是单核细胞，用生理盐水（对照）或内毒素（单核细胞激活剂）孵育枸橼酸化血液，然后测定复钙时间，应该能够得出单核细胞激活的一个指标。生理盐水孵育样本的复钙时间在健康女性和囊性增生患者中相似，但在乳腺癌患者中显著缩短。内毒素激活样本的复钙时间在乳腺癌患者中比囊性增生患者显著缩短，而囊性增生患者又比健康女性显著缩短。
