Department of Urology, University Hospital, University of Zürich, Zürich, Switzerland.
XUND Bildungszentrum Gesundheit Zentralschweiz, Luzern, Switzerland.
Semin Oncol Nurs. 2020 Aug;36(4):151042. doi: 10.1016/j.soncn.2020.151042. Epub 2020 Aug 6.
To review the indications for and side effects of androgen deprivation therapy (ADT) in men affected by prostate cancer.
National guidelines, evidence-based summaries, peer-reviewed studies, and websites.
Indications for ADT include men with (1) intermediate- to high-risk localised prostate cancer undergoing radiation therapy, (2) biochemical recurrence after radical prostatectomy treated with salvage radiation therapy, or (3) metastatic prostate cancer. Several forms of ADT are available. To support self-management, body weight, diet, physical activity, alcohol consumption, and smoking should be discussed during clinical consultations. Important side effects of ADT may include flare-up phenomena of GnRH analogues, local reactions at injection sites, cardiovascular events, bone loss/fractures, drug-drug interactions, urinary tract dysfunction, hot flashes, cognitive impairment, seizure falls, and liver impairment.
Nurses have a role in personalized cancer care and should be familiar with indications, side effects, and interventions to optimize quality of life for men affected by prostate cancer receiving ADT.
回顾雄激素剥夺疗法（ADT）在前列腺癌男性患者中的适应证和副作用。
国家指南、循证总结、同行评议研究和网站。
ADT 的适应证包括（1）局部中高危前列腺癌患者接受放疗，（2）根治性前列腺切除术后生化复发接受挽救性放疗，或（3）转移性前列腺癌。有几种形式的 ADT 可供选择。为了支持自我管理，应在临床咨询中讨论体重、饮食、身体活动、饮酒和吸烟等问题。ADT 的重要副作用可能包括 GnRH 类似物的爆发现象、注射部位的局部反应、心血管事件、骨质流失/骨折、药物相互作用、尿路功能障碍、热潮红、认知障碍、跌倒发作和肝损伤。
护士在个性化癌症护理中发挥作用，应熟悉适应证、副作用和干预措施，以优化接受 ADT 的前列腺癌男性患者的生活质量。
