The Division of Endocrinology and Metabolism, The Department of Internal Medicine, Meram Medical School of Necmettin Erbakan University, Konya, Turkey.
The Division of Endocrinology and Metabolism, The Department of Internal Medicine, Medical School of Usak University, Usak, Turkey.
Clin Investig Arterioscler. 2020 Nov-Dec;32(6):256-262. doi: 10.1016/j.arteri.2020.04.003. Epub 2020 Aug 6.
To investigate the relationship between glomerular filtration rates (GFR), and homeostasis model assesment of insulin resistance (HOMA-IR), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in patients with polycystic ovary syndrome (PCOS).
Thirty-one overweight and obese PCOS patients with body mass index (BMI)≥25kg/m and 25 non-obese PCOS patients with BMI<25kg/m were included into patients' group, while 23 overweight and obese, and 25 non-obese age-and BMI-matched healthy individuals (aged between 18 and 40 years), were enrolled as controls. Levels of serum creatinine, glucose, insulin, CRP, and complete blood count were measured. eGFR, HOMA-IR and NLR were also calculated.
In PCOS group, HOMA-IR (p=0.001), CRP (p=0.025) and waist hip ratio (WHR) (p=0.011) were higher than controls. In obese PCOS sub-group, HOMA-IR (p=0.004) and WHR (p=0.002) were higher than obese controls. In non-obese PCOS sub-group, HOMA-IR (p=0.001) were higher than non-obese controls. In obese PCOS sub-group; HOMA-IR (p=0.001) and CRP (p=0.001) levels were significantly higher than non-obese PCOS sub-group. In terms of other parameters, no significant difference was found between the groups. The analysis showed a negative correlation between GFR, and BMI and HOMA-IR in PCOS group, between GFR, WHR and insulin levels in obese PCOS sub-group, and between BMI, and HOMA-IR and NLR in non-obese PCOS sub-group.
Although HOMA-IR and CRP were higher in PCOS group, there was no difference in NLR and GFR levels between those with PCOS and controls.
探讨多囊卵巢综合征（PCOS）患者肾小球滤过率（GFR）与胰岛素抵抗稳态模型评估（HOMA-IR）、C 反应蛋白（CRP）和中性粒细胞与淋巴细胞比值（NLR）之间的关系。
将 31 名超重和肥胖的 PCOS 患者（BMI≥25kg/m²）和 25 名非肥胖的 PCOS 患者（BMI<25kg/m²）纳入患者组，同时纳入 23 名超重和肥胖的和 25 名非肥胖的年龄和 BMI 匹配的健康个体（年龄在 18 至 40 岁之间）作为对照组。测量血清肌酐、葡萄糖、胰岛素、CRP 和全血细胞计数。还计算了 eGFR、HOMA-IR 和 NLR。
在 PCOS 组中，HOMA-IR（p=0.001）、CRP（p=0.025）和腰臀比（WHR）（p=0.011）高于对照组。在肥胖的 PCOS 亚组中，HOMA-IR（p=0.004）和 WHR（p=0.002）高于肥胖的对照组。在非肥胖的 PCOS 亚组中，HOMA-IR（p=0.001）高于非肥胖的对照组。在肥胖的 PCOS 亚组中，HOMA-IR（p=0.001）和 CRP（p=0.001）水平明显高于非肥胖的 PCOS 亚组。在其他参数方面，各组之间没有差异。分析显示，在 PCOS 组中，GFR 与 BMI 和 HOMA-IR 呈负相关，在肥胖的 PCOS 亚组中，GFR 与 WHR 和胰岛素水平呈负相关，在非肥胖的 PCOS 亚组中，GFR 与 BMI、HOMA-IR 和 NLR 呈负相关。
尽管 PCOS 组的 HOMA-IR 和 CRP 较高，但 PCOS 患者与对照组之间的 NLR 和 GFR 水平没有差异。
