Monaco Andrea, Manzia Tommaso Maria, Angelico Roberta, Iaria Giuseppe, Gazia Carlo, Al Alawi Yousef, Fourtounas Konstantinos, Tisone Giuseppe, Cacciola Roberto
Department of Surgery Science, Transplant and HPB Unit, University of Rome Tor Vergata, Rome, Italy.
Department of Surgery Science, Transplant and HPB Unit, University of Rome Tor Vergata, Rome, Italy.
Transplant Proc. 2020 Nov;52(9):2607-2613. doi: 10.1016/j.transproceed.2020.07.010. Epub 2020 Jul 21.
The concerns generated by coronavirus disease 2019 (COVID-19) pandemic are having profound impact on solid organ transplantation (SOT). Non-pharmaceutical interventions (NPI) are currently the only measures available to contain COVID-19 in the general population and in more vulnerable recipients of any organ transplant. In this cross-sectional case control study from a patient survey undertaken in 2 transplant centers (TxC) in the Kingdom of Saudi Arabia and Italy, we aimed to appraise awareness of the NPI implemented by respective these governments. We have also evaluated the impact of COVID-19 on our kidney transplant (KT) recipients and a control group of kidney living donors (KLD). In our series, there were zero cases of COVID-19 among 111 KT recipients and 70 KLD of the control group. Demography, transplant type, immunosuppression regimes, and, importantly, the different COVID-19 prevalence in the 2 regions of the TxC did not appear to influence incidence of COVID-19 in our KT recipients. The absence of COVID-19 cases in our series was unexpected. Our findings suggest that awareness of NPI is associated with a successful containment of COVID-19 in vulnerable, immunosuppressed KT recipients.
2019冠状病毒病（COVID-19）大流行引发的担忧正在对实体器官移植（SOT）产生深远影响。目前，非药物干预措施（NPI）是在普通人群以及任何器官移植的更脆弱受者中控制COVID-19的唯一可用措施。在这项来自沙特阿拉伯王国和意大利的2个移植中心（TxC）进行的患者调查的横断面病例对照研究中，我们旨在评估这些政府各自实施的NPI的知晓情况。我们还评估了COVID-19对我们的肾移植（KT）受者以及肾活体供者（KLD）对照组的影响。在我们的系列研究中，111名KT受者和对照组的70名KLD中均无COVID-19病例。人口统计学、移植类型、免疫抑制方案，以及重要的是，TxC两个地区不同的COVID-19患病率似乎并未影响我们KT受者中COVID-19的发病率。我们的系列研究中没有COVID-19病例是出乎意料的。我们的研究结果表明，对NPI的知晓与在脆弱的、免疫抑制的KT受者中成功控制COVID-19有关。
