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国际心肺移植学会关于肺移植中支气管肺泡灌洗标准化的共识声明。

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.

机构信息

Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Lung Transplant Program, Division of Pulmonology, Lausanne University Hospital, Lausanne, Switzerland.

出版信息

J Heart Lung Transplant. 2020 Nov;39(11):1171-1190. doi: 10.1016/j.healun.2020.07.006. Epub 2020 Jul 15.

DOI:10.1016/j.healun.2020.07.006
PMID:32773322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7361106/
Abstract

Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation (LTx). However, BAL collection and processing are not standardized across LTx centers. This International Society for Heart and Lung Transplantation-supported consensus document on BAL standardization aims to clarify definitions and propose common approaches to improve clinical and research practice standards. The following 9 areas are covered: (1) bronchoscopy procedure and BAL collection, (2) sample handling, (3) sample processing for microbiology, (4) cytology, (5) research, (6) microbiome, (7) sample inventory/tracking, (8) donor bronchoscopy, and (9) pediatric considerations. This consensus document aims to harmonize clinical and research practices for BAL collection and processing in LTx. The overarching goal is to enhance standardization and multicenter collaboration within the international LTx community and enable improvement and development of new BAL-based diagnostics.

摘要

支气管肺泡灌洗（BAL）是肺移植（LTx）中重要的临床和研究工具。然而，LTx 中心之间的 BAL 采集和处理并未标准化。本国际心肺移植学会支持的 BAL 标准化共识文件旨在阐明定义并提出共同方法，以提高临床和研究实践标准。涵盖以下 9 个领域：（1）支气管镜检查程序和 BAL 采集，（2）样本处理，（3）微生物学样本处理，（4）细胞学，（5）研究，（6）微生物组，（7）样本库存/跟踪，（8）供体支气管镜检查，以及（9）儿科注意事项。本共识文件旨在协调 LTx 中 BAL 采集和处理的临床和研究实践。总体目标是增强国际 LTx 社区内的标准化和多中心合作，并能够改进和开发新的基于 BAL 的诊断方法。