From the Department of Pharmacy, New York-Presbyterian Hospital, New York, NY.
Cardiol Rev. 2020 Nov/Dec;28(6):332-334. doi: 10.1097/CRD.0000000000000337.
Severe acute respiratory coronavirus-2 (SARS-CoV-2) is responsible for one of the greatest public health challenges of our lifetime, the coronavirus disease 2019 (COVID-19) pandemic. Because of the complicated postinfection sequelae and grave consequences, the search for effective therapies has become a worldwide priority. The antiviral agent remdesivir has become a viable option and is now available in the United States for hospitalized patients through an emergency use authorization. This article describes remdesivir's historical background, pharmacology, key trials, adverse events, and issues regarding accessibility.
严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)引发了我们这代人面临的最严峻的公共卫生挑战之一,即 2019 年冠状病毒病(COVID-19)大流行。由于感染后的复杂后遗症和严重后果,寻找有效的治疗方法已成为全球的首要任务。抗病毒药物瑞德西韦已成为一种可行的选择,目前已通过紧急使用授权在美国为住院患者提供。本文描述了瑞德西韦的历史背景、药理学、关键试验、不良事件以及可及性问题。