Gupta Anupam K, Parker Barbara M, Priyadarshi Vikash, Parker John
Surgery, University of Miami Hospital, Miami, USA.
Clinical Pharmacy, AdventHealth Orlando, Orlando, USA.
Cureus. 2020 Oct 24;12(10):e11132. doi: 10.7759/cureus.11132.
Since December 2019, coronavirus has gradually progressed to a pandemic with no efficacious treatment. Remdesivir is an antiviral medication and inhibitor of viral RNA dependent RNA polymerase with inhibitory action against SARS-CoV virus. Two patients diagnosed with coronavirus infection with worsening respiratory status were initiated with multimodality therapy with antibiotics, steroids and remdesivir. After initiation of remdesivir, the patients' developed bradycardia, with one of the two also showing signs of worsening QT interval. This reverted upon stopping remdesvir therapy. The prevalence of bradycardia with prolonged QT interval is not well-known yet with this medication.
自2019年12月以来,冠状病毒已逐渐演变成一场大流行,且尚无有效的治疗方法。瑞德西韦是一种抗病毒药物,是病毒RNA依赖性RNA聚合酶的抑制剂,对严重急性呼吸综合征冠状病毒(SARS-CoV)具有抑制作用。两名被诊断为冠状病毒感染且呼吸状况恶化的患者开始接受抗生素、类固醇和瑞德西韦的多模式治疗。在开始使用瑞德西韦后,患者出现心动过缓,两名患者中的一名还出现QT间期延长的迹象。停用瑞德西韦治疗后,这些症状有所缓解。使用这种药物时,心动过缓伴QT间期延长的发生率尚不清楚。