Lavdaniti Maria, Margari Nikoletta, Chavela Aikaterini, Mantzanas Michalis, Chatzi Ioanna, Fradelos Evangelos C, Tilaveridis Ioannis, Tzavelas George
Nursing Department, International Hellenic University, Thessaloniki, Greece.
Nursing Department, University of West Attica, Athens, Greece.
Contemp Oncol (Pozn). 2020;24(2):112-117. doi: 10.5114/wo.2020.95853. Epub 2020 Jun 8.
To assess nausea and vomiting in cancer patients during two cycles of chemotherapy, and the impact on their quality of life.
A longitudinal study was conducted in an oncology department of a large general public hospital in Northern Greece. The sample consisted of 200 cancer patients. Data were collected with the MASCC-Antiemesis Tool and FACT-G questionnaire and specific demographic and clinical characteristics.
In cycle 2, acute vomiting was experienced by 16% of the patients and delayed vomiting by 14%; acute nausea was experienced by 27.5% and delayed nausea by 38%. In cycle 3, acute and delayed vomiting were experienced by 17.5% and 15% of the patients, respectively, acute nausea by 29.5%, and delayed nausea by 36.5%. The comparison of severity in acute vomiting between cycle 2 and cycle 3 yielded a statistically significant ( = 0.003) difference; similar results were obtained in the comparison of severity of acute nausea ( < 0.001). The correlation of severity of acute nausea with physical, emotional, and functional well-being as well as the total score of quality of life in two measurement points was statistically significant ( < 0.005). Multiple forward linear regression analysis showed that the total score of quality of life was significantly associated with age, gender, educational status, occupational status, type of cancer, family status, and diet.
Our study confirms that nausea and vomiting are significant clinical problems that influence quality of life. Further research is needed to evaluate the predictors of acute and delayed nausea and vomiting during chemotherapy.
评估癌症患者在两个化疗周期中的恶心和呕吐情况，以及对其生活质量的影响。
在希腊北部一家大型综合公立医院的肿瘤科进行了一项纵向研究。样本包括200名癌症患者。使用MASCC-止吐工具和FACT-G问卷收集数据以及特定的人口统计学和临床特征。
在第2周期，16%的患者经历了急性呕吐，14%的患者经历了延迟性呕吐；27.5%的患者经历了急性恶心，38%的患者经历了延迟性恶心。在第3周期，17.5%和15%的患者分别经历了急性和延迟性呕吐，29.5%的患者经历了急性恶心，36.5%的患者经历了延迟性恶心。第2周期和第3周期急性呕吐严重程度的比较产生了统计学显著差异（P = 0.003）；急性恶心严重程度的比较也得到了类似结果（P < 0.001）。两个测量点的急性恶心严重程度与身体、情感和功能健康以及生活质量总分之间的相关性具有统计学意义（P < 0.005）。多元向前线性回归分析表明，生活质量总分与年龄、性别、教育程度、职业状况、癌症类型、家庭状况和饮食显著相关。
我们的研究证实恶心和呕吐是影响生活质量的重要临床问题。需要进一步研究来评估化疗期间急性和延迟性恶心和呕吐的预测因素。
