微小RNA-183介导的ABI3BP缺失促进食管癌发展
The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma.
作者信息
Cai Hongfei, Li Yang, Qin Da, Wang Rui, Tang Ze, Lu Tianyu, Cui Youbin
机构信息
Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
出版信息
Mediators Inflamm. 2020 Jul 26;2020:3420946. doi: 10.1155/2020/3420946. eCollection 2020.
BACKGROUND
Esophageal cancer (EC), as a serious threat to human life and health, is one of the most common cancers around the world. Many studies have suggested that many microRNAs are involved in tumorigenesis and progression.
METHODS
To search for a novel and promising predictive therapeutic target or biomarker to achieve the goal of the early diagnosis and treatment of EC, we used the EC cell lines Eca-109 and KYSE-150 and normal human esophageal epithelial cells (HEECs) to investigate the effect of ABI3BP on EC.
RESULTS
We found that ABI family member 3 binding protein (ABI3BP) was downregulated in EC and suppressed the proliferation, activity, migration, and invasion of EC cells. ABI3BP was downregulated by miR-183, which plays the role of an oncogene.
CONCLUSION
ABI3BP and miR-183 can be considered potential biomarkers for the diagnosis of patients with EC and can be effective targets for antitumor therapy.
背景
食管癌（EC）作为对人类生命健康的严重威胁，是全球最常见的癌症之一。许多研究表明，许多微小RNA参与肿瘤的发生和发展。
方法
为寻找一种新型且有前景的预测性治疗靶点或生物标志物，以实现食管癌早期诊断和治疗的目标，我们使用食管癌细胞系Eca - 109和KYSE - 150以及正常人食管上皮细胞（HEECs）来研究ABI3BP对食管癌的影响。
结果
我们发现ABI家族成员3结合蛋白（ABI3BP）在食管癌中表达下调，并抑制食管癌细胞的增殖、活性、迁移和侵袭。ABI3BP被发挥癌基因作用的miR - 183下调。
结论
ABI3BP和miR - 183可被视为食管癌患者诊断的潜在生物标志物，并且可成为抗肿瘤治疗的有效靶点。
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