Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Key Laboratory of Agro-ecological Processes in Subtropical Region, Changsha, 410125, China.
Sci China Life Sci. 2020 Jun;63(6):866-874. doi: 10.1007/s11427-019-9591-5. Epub 2019 Nov 5.
Free radical-induced oxidative stress contributes to the development of metabolic syndromes (Mets), including overweight, hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain; under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status. Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and anti-inflammatory effect of polyphenols as potential nutritional therapy.
自由基诱导的氧化应激导致代谢综合征（Mets）的发生，包括超重、高血糖、胰岛素抵抗和促炎状态。大多数自由基来自线粒体电子传递链；在生理条件下，它们的水平通过有效的抗氧化系统来维持。已经鉴定和描述了多种转录因子，它们控制基因表达以响应氧化应激状态。天然抗氧化化合物因其强大的抗氧化能力而得到广泛研究。本综述讨论了 Mets 中氧化应激和线粒体功能障碍的最新进展，并强调了多酚的抗 Mets、抗氧化和抗炎作用，作为潜在的营养治疗方法。
