Hayashi Hiroshi, Kobayashi Ryota, Kawakatsu Shinobu, Morioka Daichi, Otani Koichi
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan.
Department of Neuropsychiatry, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
Dement Geriatr Cogn Dis Extra. 2020 Jun 10;10(2):63-68. doi: 10.1159/000507654. eCollection 2020 May-Aug.
Easy -score imaging system (eZIS)-assisted SPECT accurately detects decreases in cerebral blood flow in the posterior cingulate cortex (PCC), precuneus, and parietal lobe, the cerebral regions deeply implicated in Alzheimer's disease (AD). Several studies suggested onset age-dependent decreases in cerebral blood flow in these regions in AD, but these studies did not screen for amyloid accumulation, suggesting inclusion of non-AD patients in their subjects.
By applying eZIS-SPECT to patients with amyloid deposition, it was the aim of this study to clarify onset age-dependent decreases in cerebral blood flow in the regions critical to AD.
We retrospectively analyzed eZIS-SPECT data on 34 AD patients with amyloid retention confirmed by C-Pittsburgh compound B-PET. The subjects were divided into an early-onset group ( = 16) and a late-onset group ( = 18). The three indicators of the eZIS that had discriminated between AD patients and normal controls in previous studies were compared between the two groups.
The mean values for the respective indicators were significantly higher in the early-onset group than in the late-onset group. Also, the proportion of patients with abnormalities in all indicators was significantly higher in the early-onset group (93.8%) than in the late-onset group (50.0%).
The present study, applying eZIS-SPECT to amyloid-positive AD patients, suggests that reduced cerebral blood flow in the PCC, precuneus, and parietal lobe is more pronounced in the early-onset type than in the late-onset type of the disease.
简易评分成像系统（eZIS）辅助的单光子发射计算机断层扫描（SPECT）能够准确检测后扣带回皮质（PCC）、楔前叶和顶叶的脑血流量减少，这些脑区与阿尔茨海默病（AD）密切相关。多项研究表明，AD患者这些脑区的脑血流量会随发病年龄下降，但这些研究未筛查淀粉样蛋白积累情况，提示其研究对象中纳入了非AD患者。
本研究旨在通过将eZIS-SPECT应用于淀粉样蛋白沉积患者，阐明AD关键脑区脑血流量随发病年龄的下降情况。
我们回顾性分析了34例经C-匹兹堡化合物B正电子发射断层扫描（PET）证实有淀粉样蛋白潴留的AD患者的eZIS-SPECT数据。将研究对象分为早发型组（n = 16）和晚发型组（n = 18）。比较了两组之间在之前研究中区分AD患者和正常对照的eZIS的三个指标。
早发型组各指标的平均值显著高于晚发型组。此外，早发型组所有指标异常的患者比例（93.8%）显著高于晚发型组（50.0%）。
本研究将eZIS-SPECT应用于淀粉样蛋白阳性的AD患者，结果表明，PCC、楔前叶和顶叶的脑血流量减少在AD早发型中比晚发型更为明显。
