Kinoshita Hideyuki, Tsukanishi Toshinori, Ishii Takeshi, Kamoda Hiroto, Hagiwara Yoko, Orita Sumihisa, Inage Kazuhide, Hirosawa Naoya, Ohtori Seiji, Yonemoto Tsukasa
Department of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, Japan.
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Case Rep Dermatol Med. 2020 Jul 24;2020:4898965. doi: 10.1155/2020/4898965. eCollection 2020.
Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive, soft tissue sarcoma that is often fatal. Although there are reports describing associations of sarcoma and skin lesions such as burns, radiation, and trauma, to our knowledge, UPS development in a keloid scar has not been reported. Herein, we present the case of a 76-year-old woman who had undergone surgery for endometrial cancer, 5 years before. She presented with a protruding lesion that was continuous to a keloid scar on the abdominal wall. The tumor appeared clinically malignant as it was protruding and doubled in size within three weeks, reaching approximately 6 × 6 × 2 cm. Since the tumor was diagnosed as UPS after pathological evaluation by needle biopsy, wide resection was performed. Intraoperatively, the tumor was apparently continuous to the keloid, protruding and pedunculated outside the body, and had not invaded the abdominal cavity. Histopathological examination of the resected tumor showed evidence of UPS and no suspicion of metastasis of endometrial cancer. No recurrence, metastases, or other complications were noted 6 months after surgery. The current case study reminds us that keloids may cause high-grade sarcoma such as UPS, and careful follow-up is required.
未分化多形性肉瘤（UPS）是一种高级别、侵袭性的软组织肉瘤，通常会致命。尽管有报道描述了肉瘤与烧伤、辐射和创伤等皮肤病变之间的关联，但据我们所知，尚未有在瘢痕疙瘩中发生UPS的报道。在此，我们报告一例76岁女性患者，她在5年前接受了子宫内膜癌手术。她出现了一个突出的病变，该病变与腹壁上的瘢痕疙瘩相连。该肿瘤在临床上表现为恶性，因为它突出且在三周内大小翻倍，达到约6×6×2厘米。经针吸活检病理评估后，该肿瘤被诊断为UPS，遂进行了广泛切除。术中发现肿瘤明显与瘢痕疙瘩相连，突出于体外且有蒂，未侵犯腹腔。对切除肿瘤的组织病理学检查显示为UPS，且未怀疑有子宫内膜癌转移。术后6个月未发现复发、转移或其他并发症。本病例研究提醒我们，瘢痕疙瘩可能会引发如UPS这样的高级别肉瘤，需要进行仔细的随访。
