肺癌的早期诊断与筛查
Early diagnosis and screening in lung cancer.
作者信息
Cainap Calin, Pop Laura A, Balacescu Ovidiu, Cainap Simona S
机构信息
Department of Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
Prof. Dr. Ion Chiricuta Institute of Oncology Cluj-Napoca, Romania.
出版信息
Am J Cancer Res. 2020 Jul 1;10(7):1993-2009. eCollection 2020.
Abstract
Lung cancer is the third most diagnosed cancer, but the first cause of cancer-related deaths worldwide. This rather high death rate is due mainly to the fact that most patients are diagnosed with advanced-stage cancer, for which the conventional treatment does not work. The most used screening method for lung cancer is a low-dose CT scan, but it is recommended for specific age populations and it also started different debates on its advantages for lung cancer diagnosis. Over the year, several new techniques have been developed that are less invasive, have lower side effect, and can be implemented at all types of populations. This article aimed to present the advantages and disadvantages of using several methods for lung cancer diagnosis, including analysis of volatile organic compounds, exhaled breath condensate analysis and specific genomic approaches.
摘要
肺癌是全球第三大常见癌症，但却是癌症相关死亡的首要原因。这种相当高的死亡率主要是因为大多数患者被诊断为晚期癌症，而传统治疗方法对此无效。肺癌最常用的筛查方法是低剂量CT扫描，但它仅推荐用于特定年龄人群，并且其在肺癌诊断方面的优势也引发了不同的争论。多年来，已经开发出几种侵入性较小、副作用较低且可应用于所有类型人群的新技术。本文旨在介绍几种肺癌诊断方法的优缺点，包括挥发性有机化合物分析、呼出气冷凝物分析和特定基因组方法。
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