Dept of Chemical Engineering, Russell Berrie Nanotechnology Institute, and the Technion Integrated Cancer Center, Haifa, Israel
Dept of Chemical Engineering, Russell Berrie Nanotechnology Institute, and the Technion Integrated Cancer Center, Haifa, Israel.
Eur Respir Rev. 2019 Jun 26;28(152). doi: 10.1183/16000617.0011-2019. Print 2019 Jun 30.
This review presents and discusses a new frontier for fast, risk-free and potentially inexpensive diagnostics of respiratory diseases by detecting volatile organic compounds (VOCs) present in exhaled breath. One part of the review is a didactic presentation of the overlaying concept and the chemistry of exhaled breath. The other part discusses diverse sensors that have been developed and used for the detection of respiratory diseases ( chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, tuberculosis, cystic fibrosis, obstructive sleep apnoea syndrome and pneumoconiosis) by analysis of VOCs in exhaled breath. The strengths and pitfalls are discussed and criticised, particularly in the perspective in disseminating information regarding these advances. Ideas regarding the improvement of sensors, sensor arrays, sensing devices and the further planning of workflow are also discussed.
这篇综述介绍并讨论了通过检测呼气中存在的挥发性有机化合物（VOC）来快速、无风险且具有潜在低成本诊断呼吸疾病的新领域。综述的一部分是对呼气中挥发性有机化合物检测的覆盖概念和化学原理的教学介绍。另一部分讨论了各种已经开发并用于检测呼吸疾病（慢性阻塞性肺疾病、哮喘、肺癌、肺动脉高压、肺结核、囊性纤维化、阻塞性睡眠呼吸暂停综合征和尘肺病）的传感器，通过对呼气中 VOC 的分析来实现。讨论并批评了它们的优缺点，特别是在传播这些进展的信息方面。还讨论了有关传感器、传感器阵列、传感设备的改进以及进一步规划工作流程的想法。
