Deshwal Himanshu, Ghosh Subha, Hogan Kathleen, Akindipe Olufemi, Lane Charles Randall, Mehta Atul C
Division of Pulmonary, Critical Care and Sleep Medicine, New York University Grossman School of Medicine, New York, NY 10016, United States.
Imaging Institute, Section of Thoracic Imaging, Cleveland Clinic, Cleveland, OH 44195, United States.
World J Clin Cases. 2020 Jul 26;8(14):3031-3038. doi: 10.12998/wjcc.v8.i14.3031.
End-stage chronic obstructive pulmonary disease (COPD) is one of the common lung diseases referred for lung transplantation. According to the international society of heart and lung transplantation, 30% of all lung transplantations are carried out for COPD alone. When compared to bilateral lung transplant, single-lung transplant (SLT) has similar short-term and medium-term results for COPD. For patients with severe upper lobe predominant emphysema, lung volume reduction surgery is an excellent alternative which results in improvement in functional status and long-term mortality. In 2018, endobronchial valves were approved by the Food and Drug Administration for severe upper lobe predominant emphysema as they demonstrated improvement in lung function, exercise capacity, and quality of life. However, the role of endobronchial valves in native lung emphysema in SLT patients has not been studied.
We describe an unusual case of severe emphysema who underwent a successful SLT 15 years ago and had gradual worsening of lung function suggestive of chronic lung allograft dysfunction. However, her lung function improved significantly after a spontaneous pneumothorax of the native lung resulting in auto-deflation of large bullae.
This case highlights the clinical significance of native lung hyperinflation in single lung transplant recipient and how spontaneous decompression due to pneumothorax led to clinical improvement in our patient.
终末期慢性阻塞性肺疾病(COPD)是转诊进行肺移植的常见肺部疾病之一。根据国际心肺移植协会的数据,所有肺移植中有30%仅用于治疗COPD。与双侧肺移植相比,单肺移植(SLT)治疗COPD的短期和中期结果相似。对于以严重上叶为主的肺气肿患者,肺减容手术是一种很好的替代方法,可改善功能状态并降低长期死亡率。2018年,支气管内瓣膜被美国食品药品监督管理局批准用于严重上叶为主的肺气肿,因为它们显示出肺功能、运动能力和生活质量有所改善。然而,支气管内瓣膜在SLT患者的天然肺肺气肿中的作用尚未得到研究。
我们描述了一例不寻常的严重肺气肿病例,该患者15年前成功接受了SLT,肺功能逐渐恶化,提示慢性肺移植功能障碍。然而,在天然肺自发性气胸导致大疱自动萎陷后,她的肺功能显著改善。
本病例突出了单肺移植受者天然肺过度充气的临床意义,以及气胸导致的自发性减压如何使我们的患者临床症状得到改善。