Kanyinda Nathan, Soni Simran, Ramadan Ali, Kidwell Earl
Department of Ophthalmology, Howard University College of Medicine, 520 W St NW, Washington, DC, 20059, USA.
Am J Ophthalmol Case Rep. 2020 Jul 24;19:100842. doi: 10.1016/j.ajoc.2020.100842. eCollection 2020 Sep.
The following case describes a 28-year old African American male who presented with squamous cell carcinoma of the lacrimal duct. Despite its size and location, his tumor showed complete resolution with non-surgical treatment.
The patient presented with a 4-month history of dacryocystitis-like symptoms in the right eye, with no prior medical history and a history of tobacco smoking. Pathology indicated that SCC arose as nests within a benign sinonasal inverted papilloma. He received cisplatin chemotherapy and radiotherapy with tumor resolution in 4 months. Several months after the end of treatment, he experienced irreversible visual deterioration which led to enucleation of the right eye. The patient has remained in remission for 4 years following the treatment.
The complete resolution of the mass with non-surgical management supports the most recent literature endorsing a multidisciplinary approach for localized tumors. Our patient is the only African American identified in the literature and the youngest reported patient to present with this tumor. Most case studies have not emphasized race, ethnicity and demographics, although it is known that morbidity in malignancy is impacted by these factors.
以下病例描述了一名28岁的非裔美国男性，他患有泪道鳞状细胞癌。尽管肿瘤的大小和位置不佳，但通过非手术治疗，他的肿瘤完全消退。
患者右眼出现类似泪囊炎症状达4个月，既往无病史，有吸烟史。病理显示，鳞状细胞癌起源于良性鼻窦内翻性乳头状瘤内的巢状结构。他接受了顺铂化疗和放疗，4个月后肿瘤消退。治疗结束数月后，他出现不可逆的视力恶化，导致右眼眼球摘除。治疗后，患者已缓解4年。
非手术治疗使肿块完全消退，这支持了最近文献中支持对局部肿瘤采用多学科方法的观点。我们的患者是文献中唯一被确定的非裔美国人，也是报道中最年轻的患有这种肿瘤的患者。大多数病例研究没有强调种族、民族和人口统计学，尽管众所周知，这些因素会影响恶性肿瘤的发病率。
