Naseripour Masood, Sedaghat Ahad, Abdolalizadeh Parya, Azizi Ehsan
Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
J Curr Ophthalmol. 2020 Jul 4;32(3):297-301. doi: 10.4103/JOCO.JOCO_144_20. eCollection 2020 Jul-Sep.
To report the clinical outcome of rhuthenium-106 plaque radiotherapy in acquired retinal pigment epithelial (RPE) tumors.
In this interventional case series, two eyes of two patients with clinically diagnosed ocular-acquired RPE tumors including adenoma and adenocarcinoma underwent plaque radiotherapy with rhuthenium-106. The clinical findings and visual outcome of the patients were evaluated.
The first patient was a 44-year-old male, and the second was a 32-year-old female. The follow-up times were 24 and 32 months. The tumor was unilateral and hyperpigmented in both cases, located at juxtapapillary in one patient and on peripheral part of the retina in the other. Vitreous hemorrhage and peripheral exudation were obvious in one patient. Macular edema, epiretinal membrane, and retinal feeder vessels were also detected in the examination. The patients underwent plaque radiotherapy with rhuthenium-106 as the first step of management. The tumor has been stable until the last follow-up in both patients with globe preservation and acceptable visual acuity (5/10 for the first case and 4/10 for the second case).
Rhuthenium-106 plaque radiotherapy might be a conservative therapy in the management of acquired RPE tumors and prevent early enucleation.
报告钌 - 106敷贴放疗治疗获得性视网膜色素上皮（RPE）肿瘤的临床结果。
在这个介入性病例系列中，两名临床诊断为眼部获得性RPE肿瘤（包括腺瘤和腺癌）的患者的两只眼睛接受了钌 - 106敷贴放疗。评估了患者的临床发现和视力结果。
第一例患者为44岁男性，第二例为32岁女性。随访时间分别为24个月和32个月。两例肿瘤均为单侧且色素沉着，一例位于视乳头旁，另一例位于视网膜周边部。其中一例患者玻璃体出血和周边渗出明显。检查中还发现黄斑水肿、视网膜前膜和视网膜供养血管。患者均将钌 - 106敷贴放疗作为治疗的第一步。直到最后一次随访，两例患者的肿瘤均稳定，眼球得以保留，视力尚可（第一例为5/10，第二例为4/10）。
钌 - 106敷贴放疗可能是治疗获得性RPE肿瘤的一种保守疗法，可避免早期眼球摘除。
