Yang Fan, Zhou Xiuling, Chen Sitong, Li Qiuju, Li Ronghang, Li Chunying, Shi Chenyu, Zhu Lanyu
School of Nursing, Changchun University of Chinese Medicine, Changchun, P. R. China.
Department of Orthopedics, The Second Hospital of Jilin University, Changchun, P. R. China.
J Int Med Res. 2020 Aug;48(8):300060520935326. doi: 10.1177/0300060520935326.
This study investigated the synergistic repair effects of Prontosan hydrogel and carbon photon therapy in a rat full-thickness wound model.
The wavelength distribution of the photon source was determined. Dehydration of the Prontosan hydrogel and fibroblast viability were analyzed following exposure to different durations of light exposure at different distances from the source. Indexes of wound healing in a full-thickness rat wound model were then determined in groups ( = 8 each) subjected to either no treatment, Prontosan treatment only, carbon photon therapy only, or a combination of the two treatments (synergistic group).
Carbon photon exposure for 15 minutes at a distance of 20 cm from the wound was found to be optimal. Wound healing occurred faster in the synergistic group compared with the control and single-treatment groups. Growth factor secretion, granulation tissue formation, inflammation regulation, collagen deposition, and neovascularization were all higher in the synergistic group.
Prontosan hydrogel combined with carbon photon therapy may provide an optimal environment for wound healing and serve as a novel physical approach to the treatment of wounds. However, the number of animals included in this study was relatively small and a larger study is required to confirm these findings.
本研究在大鼠全层伤口模型中探究了普朗托散水凝胶与碳光子疗法的协同修复效果。
测定了光子源的波长分布。分析了在距光源不同距离处暴露于不同时长光照后普朗托散水凝胶的脱水情况和成纤维细胞活力。然后在未治疗、仅接受普朗托散治疗、仅接受碳光子疗法或两种治疗联合（协同组）的组（每组(n = 8)）中测定大鼠全层伤口模型的伤口愈合指标。
发现在距伤口(20)厘米处进行(15)分钟的碳光子照射是最佳的。与对照组和单一治疗组相比，协同组的伤口愈合更快。协同组的生长因子分泌、肉芽组织形成、炎症调节、胶原蛋白沉积和新血管形成均更高。
普朗托散水凝胶联合碳光子疗法可为伤口愈合提供最佳环境，并作为一种新型的伤口治疗物理方法。然而，本研究纳入的动物数量相对较少，需要更大规模的研究来证实这些发现。
