Farhangi Mahdieh Abbasalizad, Vajdi Mahdi, Fathollahi Pourya
Research Center for Evidence Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Vitam Nutr Res. 2022 Oct;92(5-6):406-422. doi: 10.1024/0300-9831/a000675. Epub 2020 Aug 11.
: In the present meta-analysis, we aimed to summarize the relationship between dietary total antioxidant capacity (TAC), general and central obesity indices and lipid profile in adult population. : The electronic databases of Web of Sciences, PubMed, Scopus and Cochrane library were searched for relevant studies from inception to October 2019. The effect size was indicated as weighted mean difference (WMD) and 95% confidence intervals (CI) by using random effects model. The I index and Cochran's Q-test were used for evaluating heterogeneity. : From 2,469 studies identified, thirty-four studies (nineteen cross-sectional studies, thirteen cohort studies, two case-control studies) were included in the meta-analysis. According to our results, higher categories of TAC were associated with significantly lower serum triglyceride concentartions (TG; WMD: -7.58; CI: -11.42, -3.75; P < 0.001) and waist circumference (WC; WMD: -1.17; 95% CI: -1.47, -0.87; P < 0.001); while no significant change in body mass index (BMI; WMD: -0.17; 95% CI: -0.35, 0.01; P = 0.12), high density lipoprotein cholesterol (HDL-C; WMD: 0.61; 95% CI: -0.16, 1.40; P = 0.12), low density lipoprotein cholesterol (LDL-C; WMD: 1.34; 95% CI: -0.61, 3.30; P = 0.17) and total cholesterol (TC; WMD: 1.19; 95% CI: -1.46, 3.855; P = 0.37) was reported. : Higher dietary TAC was related to reduced prevalence of central obesity, reduced WC and TG concentrations in the current meta-analysis. Moreover, subgroup analysis showed that TAC measurement index, geographical area, dietary assessment tool, health status and gender were potential sources of heterogeneity.
在本荟萃分析中，我们旨在总结成年人群膳食总抗氧化能力（TAC）、总体肥胖和中心性肥胖指标与血脂谱之间的关系。检索了Web of Sciences、PubMed、Scopus和Cochrane图书馆的电子数据库，以查找从数据库建立至2019年10月的相关研究。效应量采用随机效应模型表示为加权平均差（WMD）和95%置信区间（CI）。I指数和Cochrane Q检验用于评估异质性。在识别出的2469项研究中，有34项研究（19项横断面研究、13项队列研究、2项病例对照研究）纳入了荟萃分析。根据我们的结果，较高类别的TAC与显著较低的血清甘油三酯浓度（TG；WMD：-7.58；CI：-11.42，-3.75；P<0.001）和腰围（WC；WMD：-1.17；95%CI：-1.47，-0.87；P<0.001）相关；而体重指数（BMI；WMD：-0.17；95%CI：-0.35，0.01；P=0.12）、高密度脂蛋白胆固醇（HDL-C；WMD：0.61；95%CI：-0.16，1.40；P= .12）、低密度脂蛋白胆固醇（LDL-C；WMD：1.34；95%CI：-0.61，3.30；P=0.17）和总胆固醇（TC；WMD：1.19；95%CI：-1.46，3.855；P=0.37）未见显著变化。在当前的荟萃分析中，较高的膳食TAC与中心性肥胖患病率降低、WC和TG浓度降低有关。此外，亚组分析表明，TAC测量指标、地理区域、膳食评估工具、健康状况和性别是异质性的潜在来源。
