Vajdi Mahdi, Farhangi Mahdieh Abbasalizad, Mahmoudi-Nezhad Mahsa
Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Vitam Nutr Res. 2022 Oct;92(5-6):431-447. doi: 10.1024/0300-9831/a000688. Epub 2020 Nov 5.
: The available data on the relationship between dietary inflammatory index (DII) and serum lipids are controversial. This systematic review and meta-analysis aimed to investigate the relationship between DII and serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) in general populations. : PubMed, Web of Science, SCOPUS, and Cochrane electronic databases were systematically searched from inception to December 2019. Case-control, cohort or cross-sectional studies that evaluated the relationship between DII and serum lipids were included. The random-effects model was applied to evaluate the pooled weighted mean difference (WMD) and 95% confidence intervals (CI). : In total, twenty-four cross-sectional and one case-control studies with a total sample size of 129,759 were included in the meta-analysis. The pooled results showed that the highest category of DII was associated with 5.16 mg/dl increase in TC (Pooled WMD: 5.16; 95% CI: 0.58-9.73, = 0.02) and 3.99 mg/dl increase in LDL-C (Pooled WMD: 3.99; 95% CI: 1.16-6.81, = 0.006). However, no significant association between DII scores, HDL-C and TG was found. In subgroup analysis, the geographical region, gender, and dietary assessment methods were potent sources of heterogeneity. : This study showed that a higher level of DII was associated with higher levels of TC and LDL-C in apparently healthy populations. Since the included studies had observational designs, therefore, no conclusion of causality was possible. More studies with interventional designs are required to elucidate the causality of the observed association between DII and the risk of abnormal lipid profile.
关于饮食炎症指数（DII）与血脂之间关系的现有数据存在争议。本系统评价和荟萃分析旨在研究普通人群中DII与血脂之间的关系，包括总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）。从数据库建立至2019年12月，对PubMed、科学网、Scopus和Cochrane电子数据库进行了系统检索。纳入评估DII与血脂之间关系的病例对照研究、队列研究或横断面研究。采用随机效应模型评估合并加权平均差（WMD）和95%置信区间（CI）。荟萃分析共纳入24项横断面研究和1项病例对照研究，总样本量为129,759。汇总结果显示，DII最高类别与TC升高5.16mg/dl相关（合并WMD：5.16；95%CI：0.58 - 9.73，P = 0.02），与LDL-C升高3.99mg/dl相关（合并WMD：3.99；95%CI：1.16 - 6.81，P = 0.006）。然而，未发现DII评分与HDL-C和TG之间存在显著关联。在亚组分析中，地理区域、性别和饮食评估方法是异质性的重要来源。本研究表明，在明显健康的人群中，较高水平的DII与较高水平的TC和LDL-C相关。由于纳入的研究为观察性设计，因此无法得出因果关系的结论。需要更多具有干预性设计的研究来阐明DII与血脂异常风险之间观察到的关联的因果关系。
