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胸部X光片、降钙素原及莫西沙星在乳腺癌合并新型冠状病毒肺炎患者诊断与治疗中的作用

The Role of Chest Radiograph, Procalcitonin and Moxifloxacin in Diagnosis and Management of Breast Cancer Patients with COVID-19.

作者信息

Rinaldi Ikhwan, Muthalib Abdul, Astowo Pujo, Irawan Bambang, Susanto Nelly, Magdalena Lingga, Maha Ilham H R Tulus, Wicaksono Satrio

机构信息

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

出版信息

Acta Med Indones. 2020 Apr;52(2):163-171.

Abstract

Global widespread of current coronavirus disease 2019 (COVID-19) pandemic has emerged huge predicament to healthcare systems globally. This disease caused by a new beta-type coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), may lead to systemic multiorgan dysfunction syndrome and subsequently cause death due to abundant angiotensin converting enzyme 2 as its functional receptors throughout body. Oncology patients even have a worse prognosis with greater infection susceptibility because they are in a state of suppression of the systemic immune system due to malignancy and anticancer therapy. This problem makes adequate and appropriate treatment urgently needed. Through randomized clinical trials, various drugs were known to have good responses in COVID-19 patients. Here, we reported a-49-year-old-woman that was confirmed for COVID-19 by clinical manifestation, radiology profile, high procalcitonin concentration, and positive polymerase chain reaction (PCR) test. The patient also had breast and thyroid cancers history and had undergone various therapeutic modalities such as chemotherapy, thyroid surgery, and breast surgery. She was undergoing hormone therapy but experiencing disease progression after achieving complete remission based on PET-CT scan 4 months before. The patient was treated with various antibiotics but showed a significant clinical improvement by administering moxifloxacin.

摘要

当前2019冠状病毒病(COVID-19)大流行在全球范围内的传播给全球医疗系统带来了巨大困境。这种由一种新型β型冠状病毒,即严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的疾病,可能导致全身多器官功能障碍综合征,并随后由于其在全身具有丰富的血管紧张素转换酶2作为功能受体而导致死亡。肿瘤患者由于恶性肿瘤和抗癌治疗而处于全身免疫系统抑制状态,因此感染易感性更高,预后更差。这个问题使得迫切需要充分且适当的治疗。通过随机临床试验,已知多种药物对COVID-19患者有良好反应。在此,我们报告了一名49岁女性,通过临床表现、影像学特征、高降钙素原浓度以及聚合酶链反应(PCR)检测呈阳性确诊为COVID-19。该患者既往有乳腺癌和甲状腺癌病史,并接受了多种治疗方式,如化疗、甲状腺手术和乳腺手术。她正在接受激素治疗,但在4个月前基于PET-CT扫描达到完全缓解后病情出现进展。该患者接受了多种抗生素治疗,但通过给予莫西沙星后临床症状有显著改善。

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