Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Department of Respiration, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China,
Respiration. 2020;99(8):649-657. doi: 10.1159/000507940. Epub 2020 Aug 25.
A new virus broke out in Wuhan, Hubei, China, that was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical characteristics of severe pneumonia caused by SARS-CoV-2 are still not clear.
The aim of this study was to explore the clinical characteristics and risk factors of severe pneumonia caused by the SARS-CoV-2 in Wuhan, China.
The study included patients hospitalized at the Central Hospital of Wuhan who were diagnosed with COVID-19. Clinical features, chronic comorbidities, demographic data, laboratory examinations, and chest computed tomography (CT) scans were reviewed through electronic medical records. SPSS was used for data analysis to explore the clinical characteristics and risk factors of patients with severe pneumonia caused by SARS-CoV-2.
A total of 110 patients diagnosed with COVID-19 were included in the study, including 38 with severe pneumonia and 72 with nonsevere pneumonia. Statistical analysis showed that advanced age, increased D-Dimer, and decreased lymphocytes were characteristics of the patients with severe pneumonia. Moreover, in the early stage of the disease, chest CT scans of patients with severe pneumonia showed that the illness can progress rapidly.
Advanced age, decreased lymphocytes, and D-Dimer elevation are important characteristics of patients with severe COVID-19. Clinicians should focus on these characteristics to identify high-risk patients at an early stage.
一种新型病毒在中国湖北武汉爆发，后被命名为严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）。由 SARS-CoV-2 引起的重症肺炎的临床特征尚不清楚。
本研究旨在探讨中国武汉 SARS-CoV-2 引起的重症肺炎的临床特征和危险因素。
本研究纳入了在武汉市中心医院住院诊断为 COVID-19 的患者。通过电子病历回顾临床特征、慢性合并症、人口统计学数据、实验室检查和胸部计算机断层扫描（CT）。使用 SPSS 进行数据分析，以探讨 SARS-CoV-2 引起的重症肺炎患者的临床特征和危险因素。
共纳入 110 例 COVID-19 患者，其中 38 例为重症肺炎，72 例为非重症肺炎。统计分析显示，高龄、D-二聚体升高和淋巴细胞减少是重症肺炎患者的特征。此外，在疾病早期，重症肺炎患者的胸部 CT 扫描显示病情可能迅速进展。
高龄、淋巴细胞减少和 D-二聚体升高是重症 COVID-19 患者的重要特征。临床医生应关注这些特征，以便在早期识别高危患者。
