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乌干达坎帕拉贫民窟酒吧中发现人群的 HIV 感染率和细菌学确诊的肺结核率。

Prevalence of HIV infection and bacteriologically confirmed tuberculosis among individuals found at bars in Kampala slums, Uganda.

机构信息

Department of Internal Medicine, Makerere University College of Health Sciences, PO Box 7072, Kampala, Uganda.

Mulago National Referral Hospital, P.O. Box 7051, Pulmonology Division, Uganda.

出版信息

Sci Rep. 2020 Aug 10;10(1):13438. doi: 10.1038/s41598-020-70472-6.

Abstract

Individuals found at bars in slums have several risk factors for HIV and tuberculosis (TB). To determine the prevalence of HIV and TB among individuals found at bars in slums of Kampala, Uganda, we enrolled adults found at bars that provided written informed consent. Individuals with alcohol intoxication were excluded. We performed HIV testing using immunochromatographic antibody tests (Alere Determine HIV-1/2 and Chembio HIV 1/2 STAT-PAK). TB was confirmed using the Xpert MTB/RIF Ultra assay, performed on single spot sputum samples. We enrolled 272 participants from 42 bars in 5 slums. The prevalence of HIV and TB was 11.4% (95% CI 8.1-15.8) and 15 (95% CI 6-39) per 1,000 population respectively. Predictors of HIV were female sex (aOR 5.87, 95% CI 2.05-16.83), current cigarette smoking (aOR 3.23, 95% CI 1.02-10.26), history of TB treatment (aOR 10.19, 95% CI 3.17-32.82) and CAGE scores of 2-3 (aOR 3.90, 95% CI 1.11-13.70) and 4 (aOR 4.77, 95% CI 1.07-21.35). The prevalence of HIV and TB was twice and four times the national averages respectively. These findings highlight the need for concurrent programmatic screening for both HIV and TB among high risk populations in slums.

摘要

在贫民窟的酒吧中发现的个体具有多种感染艾滋病毒和结核病(TB)的风险因素。为了确定在乌干达坎帕拉的贫民窟的酒吧中发现的个体中艾滋病毒和结核病的流行率,我们招募了在提供书面知情同意的酒吧中发现的成年个体。排除了酒精中毒的个体。我们使用免疫层析抗体检测(Alere Determine HIV-1/2 和 Chembio HIV 1/2 STAT-PAK)进行艾滋病毒检测。使用 Xpert MTB/RIF Ultra 检测对单个点痰样本进行结核病确认。我们从 5 个贫民窟的 42 个酒吧中招募了 272 名参与者。艾滋病毒和结核病的患病率分别为 11.4%(95%CI 8.1-15.8)和 15(95%CI 6-39)每 1000 人。艾滋病毒的预测因素为女性(aOR 5.87,95%CI 2.05-16.83),当前吸烟(aOR 3.23,95%CI 1.02-10.26),结核病治疗史(aOR 10.19,95%CI 3.17-32.82)和 CAGE 得分 2-3(aOR 3.90,95%CI 1.11-13.70)和 4(aOR 4.77,95%CI 1.07-21.35)。艾滋病毒和结核病的患病率分别是全国平均水平的两倍和四倍。这些发现强调了在贫民窟的高危人群中同时进行艾滋病毒和结核病方案性筛查的必要性。

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