Department of Chemistry, University at Buffalo, Buffalo, New York, 14260, USA.
Department of Physics, University of Cordoba, Cordoba, 14014, Spain.
Mass Spectrom Rev. 2021 Sep;40(5):647-669. doi: 10.1002/mas.21650. Epub 2020 Aug 10.
Time-of-flight mass spectrometry (TOFMS) is one of the simplest and most powerful approaches for mass spectrometry. Realization of the advantages inherent in TOFMS requires innovation in the theory and practice of the technique. Instrumental developments, in turn, create new capabilities that enable applications in chemical measurement. This review focuses on the recent advances in TOFMS instrumentation. New strategies for ion acceleration, multiplexed detection, miniaturized TOFMS instruments, approaches to extend the length of ion flight, and novel ion detection technologies are reviewed. Techniques that change the basic paradigm of TOFMS by measuring m/z based on ion flight distance are considered, as are applications at the frontiers of instrumental performance. © 2020 John Wiley & Sons Ltd. Mass Spec Rev.
飞行时间质谱（TOFMS）是质谱中最简单、最强大的方法之一。要实现 TOFMS 固有的优势，需要在该技术的理论和实践上进行创新。反过来，仪器的发展创造了新的功能，使化学测量中的应用成为可能。本综述重点介绍了 TOFMS 仪器的最新进展。本文综述了离子加速、多路复用检测、小型化 TOFMS 仪器、延长离子飞行距离的方法以及新型离子检测技术的新策略。还考虑了基于离子飞行距离测量 m/z 来改变 TOFMS 基本范例的技术，以及仪器性能前沿的应用。© 2020 年 John Wiley & Sons Ltd. 《质谱评论》
