Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO, USA.
Methods Mol Biol. 2022;2546:1-12. doi: 10.1007/978-1-0716-2565-1_1.
Mass spectrometry is a technique that identifies analytes based on mass-to-charge (m/z) ratio and structural fragments. Although this technique has been used in research and specialized clinical laboratories for decades, only in recent years has mass spectrometry become popular in routine clinical laboratories. Mass spectrometry, especially when coupled with gas chromatography or liquid chromatography, provides very specific and often sensitive analysis of many analytes. Other advantages of mass spectrometry include simultaneous analysis of multiple analytes (>100) and generally limited requirement for specialized reagents. Commonly measured analytes by mass spectrometry include metabolites, drugs, hormones, and proteins.
质谱分析是一种基于质荷比（m/z）和结构碎片来鉴定分析物的技术。尽管该技术已经在研究和专业临床实验室中使用了几十年，但直到最近几年，质谱分析才在常规临床实验室中普及。质谱分析，特别是与气相色谱或液相色谱结合使用时，能够对许多分析物进行非常特异性且通常很灵敏的分析。质谱分析的其他优点包括同时分析多种分析物（>100 种）和通常对专用试剂的需求有限。通过质谱分析通常可以测量的分析物包括代谢物、药物、激素和蛋白质。
Zotero 插件