Pourmoshir Nadia, Motalleb G Holamreza, Vallian Sadeq
Division of Cell and Molecular Biology, Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran.
Division of Cell and Molecular Biology, Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran.
Cell J. 2020 Jul;22(Suppl 1):110-116. doi: 10.22074/cellj.2020.7011. Epub 2020 Jul 18.
Thirteen million cancer deaths and 21.7 million new cancer cases are expected in the world by 2030. Breast cancer is considered as the main cause of cancer mortality in women aged 20-59 years. microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and they are highly expressed in malignancies, including breast cancer. The role of miRNAs in the pathogenesis of breast cancer is not fully understood. In the present study, for the first time, the impact of rs6505162 on breast cancer risk was investigated in the central province of Iran, Isfahan.
This case-control study was conducted on 153 clinicopathological proven breast cancer patients and 153 sex-matched healthy women with no history of any cancer type and relative patients. The patients and controls were genotyped and association of their clinical characteristics with rs6505162 genotype was analyzed.
The findings indicated that CC genotype of rs6505162 was associated with the increased risk of breast cancer [odds ratio (OR)=2.37, 95% confidence interval (CI)=1.29-4.35 and P=0.0023, CC vs. AA].
The data suggested that rs6505162 could be considered as a novel risk factor in breast cancer pathogenesis in Isfahan province of Iran.
预计到2030年全球将有1300万例癌症死亡和2170万例新发癌症病例。乳腺癌被认为是20 - 59岁女性癌症死亡的主要原因。微小RNA（miRNA）在转录后水平调节基因表达，且在包括乳腺癌在内的恶性肿瘤中高表达。miRNA在乳腺癌发病机制中的作用尚未完全明确。在本研究中，首次在伊朗中部省份伊斯法罕调查了rs6505162对乳腺癌风险的影响。
本病例对照研究纳入153例经临床病理证实的乳腺癌患者以及153例性别匹配、无任何癌症病史且无相关家族史的健康女性。对患者和对照进行基因分型，并分析其临床特征与rs6505162基因型的相关性。
研究结果表明，rs6505162的CC基因型与乳腺癌风险增加相关[比值比（OR）=2.37，95%置信区间（CI）=1.29 - 4.35，P = 0.0023，CC与AA相比]。
数据表明，rs6505162可被视为伊朗伊斯法罕省乳腺癌发病机制中的一个新的风险因素。
