Wilson K J, Cierny G, Adams K R, Mader J T
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550-2772.
J Orthop Res. 1988;6(2):279-86. doi: 10.1002/jor.1100060216.
Both tobramycin and cefotaxime diffuse from antibiotic-impregnated polymethylmethacrylate (PMMA) beads in quantities sufficient to inhibit the growth of bacteria on agar lawns or in broth cultures over a 28-day period. Extraction of antibiotic from tobramycin or cefotaxime-impregnated PMMA beads revealed that substantial amounts of both antibiotics remained within the beads despite 28 days of diffusion. Diffusion of antibiotic from the PMMA beads during the initial 3-5 days is much greater than occurs for the remainder of the 4-week period. The results of the study suggest that perhaps tobramycin of cefotaxime-impregnated PMMA beads would produce local levels of antibiotic high enough to sterilize a given dead space for a period of 28 days.
妥布霉素和头孢噻肟均从含抗生素的聚甲基丙烯酸甲酯（PMMA）珠粒中扩散出来，其扩散量足以在28天内抑制琼脂平板或肉汤培养物中细菌的生长。从含妥布霉素或头孢噻肟的PMMA珠粒中提取抗生素后发现，尽管经过了28天的扩散，两种抗生素仍有大量残留在珠粒中。在最初的3 - 5天内，抗生素从PMMA珠粒中的扩散量远大于在接下来4周内的扩散量。该研究结果表明，或许含妥布霉素或头孢噻肟的PMMA珠粒能产生足够高的局部抗生素浓度，从而在28天内对特定死腔进行消毒。
