Shakally Almoutaz, Tahara Naoyuki, Clark Brent, Tummala Ramachandra, Caicedo-Granados Emiro, Kawakami Yasuhiko, Araki Takako
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota.
J Endocr Soc. 2020 Jul 2;4(9):bvaa089. doi: 10.1210/jendso/bvaa089. eCollection 2020 Sep 1.
Pituitary collision tumors are sporadically reported and rare. We present a case of pituitary collision tumors with nonfunctioning pituitary adenoma (NFPA) and craniopharyngioma. In order to look for any common activated pathway, we examined WNT/β-CATENIN signaling activation, known to be involved in tumorigenesis in both craniopharyngioma and NFPA. We found nuclear accumulation of β-CATENIN protein and expression of LEF1 protein, markers of active β-CATENIN signaling in the craniopharyngioma but not in the pituitary adenomas. In our case, the NFPA is invasive macroadenoma, which is a frequently identified type of pituitary adenoma in collision tumor cases. Recurrence of this tumor was first observed after 8 years of follow-up. Based on this case, we suggest that pituitary collision tumors require long-term follow-up.
垂体碰撞瘤的报道较为零散且罕见。我们报告了一例垂体碰撞瘤，包含无功能垂体腺瘤（NFPA）和颅咽管瘤。为了寻找任何共同的激活途径，我们检测了WNT/β-连环蛋白信号通路的激活情况，已知该通路参与颅咽管瘤和NFPA的肿瘤发生过程。我们发现β-连环蛋白蛋白的核内积聚以及LEF1蛋白的表达，这些是活跃的β-连环蛋白信号通路在颅咽管瘤中的标志物，但在垂体腺瘤中未发现。在我们的病例中，NFPA是侵袭性大腺瘤，这是碰撞瘤病例中常见的垂体腺瘤类型。该肿瘤在随访8年后首次出现复发。基于此病例，我们建议垂体碰撞瘤需要长期随访。
