Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Via Ariosto 35, 44100, Ferrara, Italy.
Pituitary. 2018 Apr;21(2):130-137. doi: 10.1007/s11102-018-0874-6.
The pathogenesis of non functioning pituitary adenomas (NFPA) is a complex process involving several factors, from molecular to genetic and epigenetic modifications, where tumor suppressor genes, oncogenes, cell cycle derangements have been demonstrated to play an important role. MicroRNAs (miRNAs) have also been identified as possible players in NFPA tumorigenesis and pituitary stem cells have been investigated for their potential role in pituitary tumor initiation. However, a critical role for paracrine signalling has also been highlighted. This review focuses on the current knowledge on the involvement of these factors in NFPA pathogenesis.
无功能垂体腺瘤（NFPA）的发病机制是一个复杂的过程，涉及到从分子到遗传和表观遗传修饰的几个因素，其中已证明肿瘤抑制基因、癌基因、细胞周期紊乱在其中起着重要作用。MicroRNAs（miRNAs）也被认为是 NFPA 肿瘤发生的可能参与者，而垂体干细胞也因其在垂体肿瘤发生中的潜在作用而被研究。然而，旁分泌信号的关键作用也得到了强调。本文综述了这些因素在 NFPA 发病机制中的作用的最新知识。
