Clinical Research Development Unit of Torfe Medical Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
Eye Research Center, The Five Senses Institute, Rasoul Akram Hospital, Iran University of Medical Sciences , Tehran, Iran.
Clin Exp Optom. 2021 Jan;104(1):115-118. doi: 10.1111/cxo.13117.
Botulinum toxin is commonly used for cosmetic facial rejuvenation and can result in pain at the injected site, bruising and ecchymosis, erythema and oedema, headache, diplopia, blurred vision, focal facial weakness. This study evaluates the impact of botulinum toxin on refractive error and binocular vision.
Botulinum toxin (trade name: Dysport) is a neurotoxic protein which is made from a Gram-positive anaerobic bacterium known as Clostridium botulinum. In this study, we aimed to evaluate the impact of Dysport injection on refractive error, near point of accommodation and convergence, and palpebral fissure height.
Twenty-eight subjects were treated for facial wrinkles, using Dysport. A 500-unit vial of Dysport was diluted with 2.5-ml preserved normal saline, and injected doses were 30-units for crow's feet, six units for lower eyelid wrinkles, 25 to 50-units for glabellar lines (five points), and 20 to 40 for forehead creases on four points. The refractive error, near point of accommodation and convergence and palpebral fissure heights were assessed before and two weeks after injection.
The participants comprised 23 women and five men at a mean age of 53.51 ± 14.1-years. The means of the equivalent sphere before and after injection were -0.07 ± 1.34 and -0.08 ± 1.35 (p = 0.36). The means of near point of accommodation monocularly before and after injection were 29.75 ± 6.16-cm and 26.75 ± 6.00, respectively. The means of near point of convergence before and after injection were 16.03 ± 5.27-cm and 15.55 ± 6.14, respectively (p = 0.30). The means of palpebral fissure height before and after injection were 10.33 ± 1.69-mm and 10.20 ± 1.46-mm, respectively. The changes in equivalent spherical refractive error, binocular near point of accommodation and convergence were not statistically significant.
Dysport injection for the correction of upper face animation lines, if performed at the appropriate sites and the appropriate concentration, has no significant impact on refractive error, near point of accommodation and convergence, and palpebral fissure height.
肉毒毒素常用于美容面部年轻化，可导致注射部位疼痛、瘀斑、瘀点、红斑和水肿、头痛、复视、视力模糊、局灶性面部无力。本研究评估肉毒毒素对屈光不正和双眼视觉的影响。
肉毒毒素（商品名：Dysport）是一种神经毒素蛋白，由一种称为肉毒梭菌的革兰氏阳性厌氧细菌制成。在这项研究中，我们旨在评估 Dysport 注射对面部皱纹的影响，包括屈光不正、近点调节和集合以及睑裂高度。
28 名受试者接受 Dysport 治疗面部皱纹。500 单位的 Dysport 用 2.5 毫升保存的生理盐水稀释，注射剂量为鱼尾纹 30 单位，下眼睑皱纹 6 单位，眉间线 25-50 单位（五点），额纹四点 20-40 单位。在注射前和两周后评估屈光不正、近点调节和集合以及睑裂高度。
参与者包括 23 名女性和 5 名男性，平均年龄为 53.51±14.1 岁。注射前后等效球的平均值分别为-0.07±1.34 和-0.08±1.35（p=0.36）。注射前后单眼近点调节的平均值分别为 29.75±6.16 厘米和 26.75±6.00 厘米。注射前后近点集合的平均值分别为 16.03±5.27 厘米和 15.55±6.14 厘米（p=0.30）。注射前后睑裂高度的平均值分别为 10.33±1.69 毫米和 10.20±1.46 毫米。等效球面屈光不正、双眼近点调节和集合的变化无统计学意义。
Dysport 注射用于矫正上面部动画线，如果在适当的部位和适当的浓度下进行，对屈光不正、近点调节和集合以及睑裂高度没有显著影响。
