Huang Chang-Ming, Sheen Yi-Shuan, Liao Yi-Hua
Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.
Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
J Cosmet Dermatol. 2025 Jun;24(6):e70274. doi: 10.1111/jocd.70274.
The 1927-nm nonablative fractional laser is widely used for skin rejuvenation and hyperpigmentation. However, its efficacy and safety for periorbital rejuvenation remain uncertain.
To assess the effects of the 1927-nm nonablative fractional diode laser on periorbital rejuvenation.
PATIENTS/METHODS: Twenty participants were randomized into two groups and received three treatments at 2-week (Group A) or 4-week (Group B) intervals. Clinical efficacy was assessed using ANTERA 3D, blinded investigator-rated scores, and subject self-assessments.
Both group A and group B exhibited statistically significant improvements in L* (color measurement which indicates lightness) and pigmentation score at the end-of-study visit compared to baseline, with group B also achieving statistically significant enhancement in the pores' index and wrinkles' score. Group B showed greater improvement in wrinkles' score compared to group A at the end-of-study visit. The median of Global Aesthetic Improvement Scale assessed by both the physicians and subjects showed improvement, ranging from "improved" to "much improved" at the end-of-study visit. Transient side effects including tenderness, erythema, swelling, and scaling were observed, with the majority resolving within 7 days.
The 1927-nm diode laser is an effective and safe option for periorbital rejuvenation. The 4-week interval treatment appears to be the preferable option due to its superior improvement in the wrinkles' score at the end of the study. The positive changes in skin brightness and the reduction of brown spots represented additional benefits, setting it apart as a notable alternative to other ablative and nonablative fractional lasers.
1927纳米非剥脱性分数激光被广泛用于皮肤年轻化和色素沉着治疗。然而，其用于眶周年轻化的疗效和安全性仍不确定。
评估1927纳米非剥脱性二极管激光对眶周年轻化的效果。
患者/方法：20名参与者被随机分为两组，分别以2周（A组）或4周（B组）的间隔接受三次治疗。使用ANTERA 3D、盲法研究者评分和受试者自我评估来评估临床疗效。
与基线相比，A组和B组在研究结束时L*值（表示亮度的颜色测量值）和色素沉着评分均有统计学显著改善，B组在毛孔指数和皱纹评分方面也有统计学显著提高。在研究结束时，B组在皱纹评分方面比A组有更大改善。医生和受试者评估的全球美容改善量表中位数均显示有改善，在研究结束时从“改善”到“显著改善”不等。观察到包括压痛、红斑、肿胀和脱屑在内的短暂副作用，大多数在7天内消退。
1927纳米二极管激光是眶周年轻化的有效且安全的选择。4周间隔治疗似乎是更优选择，因为在研究结束时其在皱纹评分方面有更优改善。皮肤亮度的积极变化和褐色斑点的减少是额外的益处，使其成为其他剥脱性和非剥脱性分数激光的显著替代方案。
