Ghonemy Soheir, Ibrahim Ali Mahitab, Ebrahim Howyda Mohamed
Faculty of Medicine, Department of Dermatology, Zagazig University, Zagazig, Egypt.
Dermatol Ther. 2020 Nov;33(6):e14179. doi: 10.1111/dth.14179. Epub 2020 Sep 10.
Intralesional 5-fluorouracil (IL5-FU) has been used off-label for warts treatment; however, its use was limited by intense pain. Combination treatment can offer a robust therapeutic effect. Was to assess the therapeutic efficacy, safety and tolerability of microneedling vs its combination with 5-FU solution vs IL5-FU in the treatment of plantar warts. Ninety patients with plantar warts were divided randomly into three groups each containing 30 patients. Group A received (intralesional 5-FU), group B (microneedling) while group C (microneedling and 5-FU solution). All groups received treatment for a maximum of six sessions 2 weeks apart. Complete response was observed in 86.7% of the warts treated with 5-FU and microneedling (group C) vs to 76.7% and 70% in group A and B, respectively, with no statistically significant difference (P = .36). A significant increase in the number of sessions (P = .01) and pain score (P = .001) were found among group A compared to groups B and C. Patient's satisfaction was higher in group C (P = .05). No recurrence was reported in all groups. Microneedling can be used as alternative or adjuvant therapeutic modality for plantar warts treatment and significantly associated with less pain. Combination group was superior compared to the others.
病灶内注射5-氟尿嘧啶（IL5-FU）已被用于疣治疗的非标签用途；然而，其使用受到剧烈疼痛的限制。联合治疗可提供强大的治疗效果。旨在评估微针治疗、微针联合5-FU溶液与IL5-FU治疗跖疣的疗效、安全性和耐受性。90例跖疣患者随机分为三组，每组30例。A组接受（病灶内注射5-FU），B组接受（微针治疗），而C组接受（微针和5-FU溶液）。所有组均接受治疗，最多6个疗程，间隔2周。接受5-FU和微针治疗（C组）的疣中，86.7%观察到完全缓解，而A组和B组分别为76.7%和70%，无统计学显著差异（P = 0.36）。与B组和C组相比，A组的疗程数（P = 0.01）和疼痛评分（P = 0.001）显著增加。C组患者满意度更高（P = 0.05）。所有组均未报告复发。微针可作为跖疣治疗的替代或辅助治疗方式，且与较少疼痛显著相关。联合组优于其他组。
