Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka 410001, Nigeria.
Department of Chemistry, School of Physical and Chemical Science, University of Canterbury, Christchurch 8041, New Zealand.
ACS Comb Sci. 2020 Nov 9;22(11):543-553. doi: 10.1021/acscombsci.0c00082. Epub 2020 Aug 24.
Active metabolites from natural sources are the predominant molecular targets in numerous biological studies owing to their appropriate compatibility with biological systems and desirable selective toxicities. Thus, their potential for therapeutic development could span a broad scope of disease areas, including pathological and neurological dysfunctions. Cardiac glycosides are a unique class of specialized metabolites that have been extensively applied as therapeutic agents for the treatment of numerous heart conditions, and more recently, they have also been explored as probable antitumor agents. They are a class of naturally derived compounds that bind to and inhibit Na/K-ATPase. This study presents cardiac glycosides and their analogues with highlights on their applications, challenges, and prospects as lead compounds for cancer treatment.
天然来源的活性代谢物是许多生物研究中的主要分子靶点，因为它们与生物系统具有适当的相容性和理想的选择性毒性。因此，它们在治疗开发方面的潜力可能涵盖广泛的疾病领域，包括病理和神经功能障碍。强心苷是一类独特的特殊代谢物，已广泛应用于治疗多种心脏疾病的治疗药物，最近也被探索作为潜在的抗肿瘤药物。它们是一类与 Na/K-ATPase 结合并抑制其活性的天然衍生化合物。本研究介绍了强心苷及其类似物，并重点介绍了它们作为癌症治疗的先导化合物的应用、挑战和前景。
