El-Saadony Mohamed T, Saad Ahmed M, Mohammed Dina Mostafa, Korma Sameh A, Alshahrani Mohammad Y, Ahmed Ahmed Ezzat, Ibrahim Essam H, Salem Heba M, Alkafaas Samar Sami, Saif Abdullah M, Elkafas Sara Samy, Fahmy Mohamed A, Abd El-Mageed Taia A, Abady Mariam M, Assal Hanya Y, El-Tarabily Marawan K, Mathew Betty T, AbuQamar Synan F, El-Tarabily Khaled A, Ibrahim Salam A
Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Front Immunol. 2025 Apr 28;16:1491777. doi: 10.3389/fimmu.2025.1491777. eCollection 2025.
In recent years, medicinal plants have gained significant attention in modern medicine due to their accessibility, affordability, widespread acceptance, and safety, making herbal remedies highly valued globally. Consequently, ensuring medicinal plants' quality, efficacy, and safety has become a critical concern for developed and developing nations. The emergence of multidrug-resistant microorganisms poses a serious global health threat, particularly in low-income regions, despite significant advancements in antimicrobial drugs and medical research over the past century. The rapid spread of these multidrug-resistant infections is primarily attributed to improper prescriptions, overuse, and unregulated access to antibiotics. Addressing these challenges, the standardization of plant-derived pharmaceuticals could pave the way for a transformative era in healthcare. Preserving and leveraging the historical knowledge of medicinal plants is essential before such valuable information is lost. Recently, there has been growing interest among natural and pharmaceutical scientists in exploring medicinal plants as potential sources of antimicrobial agents. This current review aims to identify the most common pathogens threatening human health, analyze the factors contributing to the rise of drug-resistant microorganisms, and evaluate the widespread use of medicinal plants across various countries as alternative antibiotics, highlighting their unique mechanisms of antimicrobial resistance.
近年来，药用植物因其易获取、价格亲民、广泛被接受且安全等特点，在现代医学中受到了广泛关注，这使得草药疗法在全球备受重视。因此，确保药用植物的质量、功效和安全性已成为发达国家和发展中国家的关键关切。尽管在过去一个世纪里抗菌药物和医学研究取得了重大进展，但多重耐药微生物的出现对全球健康构成了严重威胁，尤其是在低收入地区。这些多重耐药感染的迅速传播主要归因于不当处方、过度使用以及抗生素的无节制获取。为应对这些挑战，植物源药物的标准化可为医疗保健领域的变革时代铺平道路。在这些宝贵信息丢失之前，保护和利用药用植物的历史知识至关重要。最近，天然科学家和制药科学家对探索药用植物作为抗菌剂的潜在来源越来越感兴趣。本综述旨在确定威胁人类健康的最常见病原体，分析导致耐药微生物增多的因素，并评估药用植物在各国作为替代抗生素的广泛使用情况，突出其独特的抗菌耐药机制。
